OBJECTIVE: We reported the anti-inflammatory action of diphenyl diselenide [(PhSe)(2)] in an acute inflammation model induced by carrageenan. MATERIALS: Male adult Swiss mice. METHODS: Mice were treated with (PhSe)(2) (50 mg/kg) or vehicle (10 ml/kg) per oral route. After 30 min, animals received saline (0.1 ml) or saline containing 1 % carrageenan (0.1 ml) into the pleural cavity. Total and differential leukocyte counts, myeloperoxidase (MPO) activity, pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and interferon (INF)-γ] and reactive species (RS) were determined in pleural fluids. Pleural exudate accumulation was determined by Evans blue assay. Statistical analysis was performed by using a two-way ANOVA followed by the Duncan's test. RESULTS: (PhSe)(2) treatment was effective against the increase in total and differential leukocyte counts, MPO activity, RS levels and pleural exudate caused by carrageenan. (PhSe)(2) partially protected against the increase in TNF-α, IL-1β, IL-6 and INF-γ levels induced by carrageenan. (PhSe)(2) had a similar anti-inflammatory profile to that of dexamethasone. CONCLUSION: The anti-inflammatory property of (PhSe)(2) was demonstrated in the mouse model of pleurisy induced by carrageenan. The antioxidant property of (PhSe)(2) is related, at least in part, to the anti-inflammatory action of this compound.
OBJECTIVE: We reported the anti-inflammatory action of diphenyl diselenide [(PhSe)(2)] in an acute inflammation model induced by carrageenan. MATERIALS: Male adult Swiss mice. METHODS:Mice were treated with (PhSe)(2) (50 mg/kg) or vehicle (10 ml/kg) per oral route. After 30 min, animals received saline (0.1 ml) or saline containing 1 % carrageenan (0.1 ml) into the pleural cavity. Total and differential leukocyte counts, myeloperoxidase (MPO) activity, pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and interferon (INF)-γ] and reactive species (RS) were determined in pleural fluids. Pleural exudate accumulation was determined by Evans blue assay. Statistical analysis was performed by using a two-way ANOVA followed by the Duncan's test. RESULTS: (PhSe)(2) treatment was effective against the increase in total and differential leukocyte counts, MPO activity, RS levels and pleural exudate caused by carrageenan. (PhSe)(2) partially protected against the increase in TNF-α, IL-1β, IL-6 and INF-γ levels induced by carrageenan. (PhSe)(2) had a similar anti-inflammatory profile to that of dexamethasone. CONCLUSION: The anti-inflammatory property of (PhSe)(2) was demonstrated in the mouse model of pleurisy induced by carrageenan. The antioxidant property of (PhSe)(2) is related, at least in part, to the anti-inflammatory action of this compound.
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