Literature DB >> 22698908

An unusual presentation of breast cancer in a very young woman.

Nicole P Sandhu1, Harry J Long, Kiley J Johnson, Amy C Degnim.   

Abstract

A healthy 27-year-old woman presented to an outside institution with unilateral nipple pruritus and a slight brown discolouration. When her symptoms failed to respond to topical therapy, nipple biopsy revealed Paget's disease of the nipple. The patient sought further evaluation and care at our institution. Further investigation revealed multifocal breast cancer and the patient underwent bilateral mastectomies with sentinel lymph node biopsy followed by adjuvant systemic therapy. She is currently more than 4 years out from surgery and chemotherapy and has had no evidence of breast cancer recurrence.

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Year:  2011        PMID: 22698908      PMCID: PMC3063299          DOI: 10.1136/bcr.12.2010.3590

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  17 in total

Review 1.  ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics.

Authors:  K McPherson; C M Steel; J M Dixon
Journal:  BMJ       Date:  2000-09-09

Review 2.  Nevoid hyperkeratosis of the nipple and/or areola: a report of two cases and a review of the literature.

Authors:  Ravi S Krishnan; Tiffany A Angel; Tom R Roark; Sylvia Hsu
Journal:  Int J Dermatol       Date:  2002-11       Impact factor: 2.736

3.  Paget's disease of the nipple.

Authors:  A R Dixon; M H Galea; I O Ellis; C W Elston; R W Blamey
Journal:  Br J Surg       Date:  1991-06       Impact factor: 6.939

Review 4.  Paget's disease of the breast.

Authors:  G H Sakorafas; K Blanchard; M G Sarr; D R Farley
Journal:  Cancer Treat Rev       Date:  2001-02       Impact factor: 12.111

5.  Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.

Authors:  A Antoniou; P D P Pharoah; S Narod; H A Risch; J E Eyfjord; J L Hopper; N Loman; H Olsson; O Johannsson; A Borg; B Pasini; P Radice; S Manoukian; D M Eccles; N Tang; E Olah; H Anton-Culver; E Warner; J Lubinski; J Gronwald; B Gorski; H Tulinius; S Thorlacius; H Eerola; H Nevanlinna; K Syrjäkoski; O-P Kallioniemi; D Thompson; C Evans; J Peto; F Lalloo; D G Evans; D F Easton
Journal:  Am J Hum Genet       Date:  2003-04-03       Impact factor: 11.025

6.  Paget's disease of the breast.

Authors:  F C Nance; D H DeLoach; R A Welsh; W F Becker
Journal:  Ann Surg       Date:  1970-06       Impact factor: 12.969

7.  Paget's disease of the breast.

Authors:  R Ashikari; K Park; A G Huvos; J A Urban
Journal:  Cancer       Date:  1970-09       Impact factor: 6.860

8.  Paget disease of the nipple: a multifocal manifestation of higher-risk disease.

Authors:  Ashutosh S Kothari; Nicolas Beechey-Newman; Hisham Hamed; Ian S Fentiman; Corrado D'Arrigo; Andrew M Hanby; Ken Ryder
Journal:  Cancer       Date:  2002-07-01       Impact factor: 6.860

9.  Pathogenesis and treatment of Paget's disease of the breast.

Authors:  J F Paone; R R Baker
Journal:  Cancer       Date:  1981-08-01       Impact factor: 6.860

10.  Paget's disease of the nipple: a ten year review including clinical, pathological, and immunohistochemical findings.

Authors:  M A Chaudary; R R Millis; E B Lane; N A Miller
Journal:  Breast Cancer Res Treat       Date:  1986       Impact factor: 4.872

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