OBJECTIVE: To assess the association between self-reported measures of stress, anxiety, depression, and related constructs and fecundity. DESIGN: Prospective cohort study of women trying to conceive. SETTING: United Kingdom. PATIENT(S): Three hundred thirty-nine women aged 18-40 years who were attempting to conceive. INTERVENTION(S): Completed daily diaries for up to six cycles or until pregnancy was detected. For each cycle, stress biomarkers were measured and psychosocial questionnaires were completed. MAIN OUTCOME MEASURES(S): Fecundability odds ratios (FORs) and 95% confidence intervals were calculated using discrete time survival methods, and the day-specific probabilities of pregnancy were calculated using Bayesian statistical techniques. RESULT(S): Among the 339 women, 207 (61%) became pregnant during the study, 69 (20%) did not become pregnant, and 63 (19%) withdrew. After controlling for maternal age, parity, months trying to conceive before enrollment, smoking, caffeine use, and frequency of intercourse, we found no association between most psychosocial measures and FORs or the day-specific probabilities of pregnancy save for an increased FOR for women reporting higher versus lower levels of social support. CONCLUSION(S): Self-reported psychosocial stress, anxiety, and depression were not associated with fecundity. Any adverse effect of stress or psychological disturbance on fecundity does not appear to be detectable via the questionnaires administered.
OBJECTIVE: To assess the association between self-reported measures of stress, anxiety, depression, and related constructs and fecundity. DESIGN: Prospective cohort study of women trying to conceive. SETTING: United Kingdom. PATIENT(S): Three hundred thirty-nine women aged 18-40 years who were attempting to conceive. INTERVENTION(S): Completed daily diaries for up to six cycles or until pregnancy was detected. For each cycle, stress biomarkers were measured and psychosocial questionnaires were completed. MAIN OUTCOME MEASURES(S): Fecundability odds ratios (FORs) and 95% confidence intervals were calculated using discrete time survival methods, and the day-specific probabilities of pregnancy were calculated using Bayesian statistical techniques. RESULT(S): Among the 339 women, 207 (61%) became pregnant during the study, 69 (20%) did not become pregnant, and 63 (19%) withdrew. After controlling for maternal age, parity, months trying to conceive before enrollment, smoking, caffeine use, and frequency of intercourse, we found no association between most psychosocial measures and FORs or the day-specific probabilities of pregnancy save for an increased FOR for women reporting higher versus lower levels of social support. CONCLUSION(S): Self-reported psychosocial stress, anxiety, and depression were not associated with fecundity. Any adverse effect of stress or psychological disturbance on fecundity does not appear to be detectable via the questionnaires administered.
Authors: Cecilia Pyper; Lise Bromhall; Sarah Dummett; Douglas G Altman; Pat Brownbill; Michael Murphy Journal: Paediatr Perinat Epidemiol Date: 2006-11 Impact factor: 3.980
Authors: Fatemeh Ramezanzadeh; Ahmad-Ali Noorbala; Nasrin Abedinia; Abbas Rahimi Forooshani; Mohammad Mehdi Naghizadeh Journal: Malays J Med Sci Date: 2011-01
Authors: N H Hjollund; T K Jensen; J P Bonde; T B Henriksen; A M Andersson; H A Kolstad; E Ernst; A Giwercman; N E Skakkebaek; J Olsen Journal: Fertil Steril Date: 1999-07 Impact factor: 7.329
Authors: Nanette Santoro; Esther Eisenberg; J C Trussell; LaTasha B Craig; Clarisa Gracia; Hao Huang; Ruben Alvero; Peter Casson; Gregory Christman; Christos Coutifaris; Michael Diamond; Susan Jin; Richard S Legro; Randal D Robinson; William D Schlaff; Heping Zhang Journal: Hum Reprod Date: 2016-07-07 Impact factor: 6.918
Authors: Amelia K Wesselink; Elizabeth E Hatch; Kenneth J Rothman; Jennifer L Weuve; Ann Aschengrau; Rebecca J Song; Lauren A Wise Journal: Am J Epidemiol Date: 2018-12-01 Impact factor: 4.897
Authors: Jihye Park; Joseph B Stanford; Christina A Porucznik; Kylie Christensen; Karen C Schliep Journal: Psychoneuroendocrinology Date: 2019-09-16 Impact factor: 4.905
Authors: Karen C Schliep; Sunni L Mumford; Catherine J Vladutiu; Katherine A Ahrens; Neil J Perkins; Lindsey A Sjaarda; Kerri A Kissell; Ankita Prasad; Jean Wactawski-Wende; Enrique F Schisterman Journal: Epidemiology Date: 2015-03 Impact factor: 4.822
Authors: Karl R Hansen; Amy Linnea W He; Aaron K Styer; Robert A Wild; Samantha Butts; Lawrence Engmann; Michael P Diamond; Richard S Legro; Christos Coutifaris; Ruben Alvero; Randal D Robinson; Peter Casson; Gregory M Christman; Hao Huang; Nanette Santoro; Esther Eisenberg; Heping Zhang Journal: Fertil Steril Date: 2016-03-03 Impact factor: 7.329