| Literature DB >> 22698431 |
Aymen Lagha1, Nesrine Chraiet2, Mouna Ayadi2, Sarra Krimi2, Bassem Allani2, Hela Rifi2, Henda Raies2, Amel Mezlini2.
Abstract
Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers.Entities:
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Year: 2012 PMID： 22698431 DOI： 10.1016/j.oraloncology.2012.05.004
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337