Literature DB >> 22698396

Silencing the killers: paracrine immune suppression in pancreatic cancer.

Adrienne D Cox1, Kenneth P Olive.   

Abstract

Pancreatic cancers are characterized by high levels of inflammatory cells and profound immune suppression. In this issue of Cancer Cell, Bayne et al. and Pylayeva-Gupta et al. show that KRAS-driven, tumor cell-secreted GM-CSF recruits myeloid-derived suppressor cells to the stroma to abrogate tumor cell immune clearance by killer T lymphocytes.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22698396     DOI： 10.1016/j.ccr.2012.05.029

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  5 in total

Review 1.  Obesity and cancer: inflammation bridges the two.

Authors:  Ryan Kolb; Fayyaz S Sutterwala; Weizhou Zhang
Journal:  Curr Opin Pharmacol       Date:  2016-07-16       Impact factor: 5.547

2.  GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro.

Authors:  Tessa Gargett; Susan N Christo; Timothy R Hercus; Nazim Abbas; Nimit Singhal; Angel F Lopez; Michael P Brown
Journal:  Clin Transl Immunology       Date:  2016-12-23

3.  Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma.

Authors:  Jing Liu; Wenna Jiang; Kaili Zhao; Hongwei Wang; Tianxing Zhou; Weiwei Bai; Xiuchao Wang; Tiansuo Zhao; Chongbiao Huang; Song Gao; Tai Qin; Wenwen Yu; Bo Yang; Xin Li; Danqi Fu; Wei Tan; Shengyu Yang; He Ren; Jihui Hao
Journal:  J Exp Med       Date:  2019-02-07       Impact factor: 14.307

4.  Arousal of cancer-associated stromal fibroblasts: palladin-activated fibroblasts promote tumor invasion.

Authors:  Teresa A Brentnall
Journal:  Cell Adh Migr       Date:  2012-10-17       Impact factor: 3.405

Review 5.  Genetics and biology of pancreatic ductal adenocarcinoma.

Authors:  Haoqiang Ying; Prasenjit Dey; Wantong Yao; Alec C Kimmelman; Giulio F Draetta; Anirban Maitra; Ronald A DePinho
Journal:  Genes Dev       Date:  2016-02-15       Impact factor: 11.361
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.