Literature DB >> 22698394

CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction.

Joan Font-Burgada1, Ekihiro Seki, Michael Karin.   

Abstract

Hepatocellular carcinoma is the outcome of ongoing cycles of cell death and regeneration in chronic liver disease. In this issue of Cancer Cell, Nikolaou et al. show that the deubiquitinating enzyme CYLD is critical for controlling the balance between hepatocyte loss, regeneration, and malignant progression.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22698394      PMCID： PMC4718070          DOI： 10.1016/j.ccr.2012.05.034

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  8 in total

1.  TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.

Authors:  Kira Bettermann; Mihael Vucur; Johannes Haybaeck; Christiane Koppe; Jörn Janssen; Felix Heymann; Achim Weber; Ralf Weiskirchen; Christian Liedtke; Nikolaus Gassler; Michael Müller; Rita de Vos; Monika Julia Wolf; Yannick Boege; Gitta Maria Seleznik; Nicolas Zeller; Daniel Erny; Thomas Fuchs; Stefan Zoller; Stefano Cairo; Marie-Annick Buendia; Marco Prinz; Shizuo Akira; Frank Tacke; Mathias Heikenwalder; Christian Trautwein; Tom Luedde
Journal:  Cancer Cell       Date:  2010-05-18       Impact factor: 31.743

2.  Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation.

Authors:  Toshiharu Sakurai; Shin Maeda; Lufen Chang; Michael Karin
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-28       Impact factor: 11.205

3.  Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.

Authors:  Dianne H Dapito; Ali Mencin; Geum-Youn Gwak; Jean-Philippe Pradere; Myoung-Kuk Jang; Ingmar Mederacke; Jorge M Caviglia; Hossein Khiabanian; Adebowale Adeyemi; Ramon Bataller; Jay H Lefkowitch; Maureen Bower; Richard Friedman; R Balfour Sartor; Raul Rabadan; Robert F Schwabe
Journal:  Cancer Cell       Date:  2012-04-17       Impact factor: 31.743

4.  Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma.

Authors:  Tom Luedde; Naiara Beraza; Vasileios Kotsikoris; Geert van Loo; Arianna Nenci; Rita De Vos; Tania Roskams; Christian Trautwein; Manolis Pasparakis
Journal:  Cancer Cell       Date:  2007-02       Impact factor: 31.743

5.  IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.

Authors:  Shin Maeda; Hideaki Kamata; Jun-Li Luo; Hyam Leffert; Michael Karin
Journal:  Cell       Date:  2005-07-01       Impact factor: 41.582

6.  Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis.

Authors:  Sayaka Inokuchi; Tomonori Aoyama; Kouichi Miura; Christoph H Osterreicher; Yuzo Kodama; Katsumi Miyai; Shizuo Akira; David A Brenner; Ekihiro Seki
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-18       Impact factor: 11.205

7.  NF-kappaB functions as a tumour promoter in inflammation-associated cancer.

Authors:  Eli Pikarsky; Rinnat M Porat; Ilan Stein; Rinat Abramovitch; Sharon Amit; Shafika Kasem; Elena Gutkovich-Pyest; Simcha Urieli-Shoval; Eithan Galun; Yinon Ben-Neriah
Journal:  Nature       Date:  2004-08-25       Impact factor: 49.962

8.  Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.

Authors:  Kostas Nikolaou; Ageliki Tsagaratou; Christina Eftychi; George Kollias; George Mosialos; Iannis Talianidis
Journal:  Cancer Cell       Date:  2012-06-12       Impact factor: 31.743
  8 in total
  3 in total

1.  Downregulation of miR-362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cells.

Authors:  Fang Ni; Zhaohua Gui; Qiang Guo; Zhongqian Hu; Xinyi Wang; Danlei Chen; Siying Wang
Journal:  Oncol Lett       Date:  2015-12-03       Impact factor: 2.967

2.  Genetic alterations in TRAF3 and CYLD that regulate nuclear factor κB and interferon signaling define head and neck cancer subsets harboring human papillomavirus.

Authors:  Tony Chen; Jialing Zhang; Zhong Chen; Carter Van Waes
Journal:  Cancer       Date:  2017-03-13       Impact factor: 6.860

3.  miR‑197‑3p‑induced downregulation of lysine 63 deubiquitinase promotes cell proliferation and inhibits cell apoptosis in lung adenocarcinoma cell lines.

Authors:  Yang Chen; Chunlu Yang
Journal:  Mol Med Rep       Date:  2017-12-20       Impact factor: 2.952
  3 in total

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