| Literature DB >> 22698383 |
Marieke Op de Beeck1, Annemieke Madder.
Abstract
A new biocompatible strategy for photoinduced DNA interstrand cross-linking is presented. Methylene blue induced (1)O(2) formation triggers furan oxidation; the resulting aldehyde then rapidly reacts with complementary A or C with formation of stable adducts. Easily accessible furan modified nucleosides, a commercially available photosensitizer, and visible light irradiation constitute the necessary tools to achieve selective duplex interstrand cross-linking.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22698383 DOI： 10.1021/ja301901p
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419