Literature DB >> 22696036

The platelet-derived growth factor (PDGF) family of tyrosine kinase receptors: a Kit to fix the beta cell?

M Welsh1.   

Abstract

Overexpression of c-Kit has recently been shown to ameliorate beta cell function by increasing the beta cell mass and insulin secretion, thus counteracting the deleterious effects of a high-fat diet on glucose homeostasis. The c-Kit-dependent effects are due to enhanced Akt activity that phosphorylates and inhibits glycogen synthase kinase 3β (GSK3β), thereby increasing the expression of numerous genes that promote insulin production and cell proliferation. Regulating the c-Kit/Akt/GSK3β pathway may provide novel means for improving beta cell function in type 2 diabetes.

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Year:  2012        PMID： 22696036     DOI： 10.1007/s00125-012-2611-4

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  23 in total

1.  Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation.

Authors:  Lieven Thorrez; Ilaria Laudadio; Katrijn Van Deun; Roel Quintens; Nico Hendrickx; Mikaela Granvik; Katleen Lemaire; Anica Schraenen; Leentje Van Lommel; Stefan Lehnert; Cristina Aguayo-Mazzucato; Rui Cheng-Xue; Patrick Gilon; Iven Van Mechelen; Susan Bonner-Weir; Frédéric Lemaigre; Frans Schuit
Journal:  Genome Res       Date:  2010-11-18       Impact factor: 9.043

Review 2.  Signal transduction via the stem cell factor receptor/c-Kit.

Authors:  L Rönnstrand
Journal:  Cell Mol Life Sci       Date:  2004-10       Impact factor: 9.261

3.  Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.

Authors:  Struan F A Grant; Gudmar Thorleifsson; Inga Reynisdottir; Rafn Benediktsson; Andrei Manolescu; Jesus Sainz; Agnar Helgason; Hreinn Stefansson; Valur Emilsson; Anna Helgadottir; Unnur Styrkarsdottir; Kristinn P Magnusson; G Bragi Walters; Ebba Palsdottir; Thorbjorg Jonsdottir; Thorunn Gudmundsdottir; Arnaldur Gylfason; Jona Saemundsdottir; Robert L Wilensky; Muredach P Reilly; Daniel J Rader; Yu Bagger; Claus Christiansen; Vilmundur Gudnason; Gunnar Sigurdsson; Unnur Thorsteinsdottir; Jeffrey R Gulcher; Augustine Kong; Kari Stefansson
Journal:  Nat Genet       Date:  2006-01-15       Impact factor: 38.330

4.  A search for tyrosine kinase receptors expressed in the rat embryonic pancreas.

Authors:  S LeBras; P Czernichow; R Scharfmann
Journal:  Diabetologia       Date:  1998-12       Impact factor: 10.122

5.  Effects of platelet-derived growth factor and somatomedin-C/insulin-like growth factor I on the deoxyribonucleic acid replication of fetal rat islets of Langerhans in tissue culture.

Authors:  I Swenne; C H Heldin; D J Hill; C Hellerström
Journal:  Endocrinology       Date:  1988-01       Impact factor: 4.736

6.  Stem cell factor/c-Kit interactions regulate human islet-epithelial cluster proliferation and differentiation.

Authors:  Jinming Li; Cynthia G Goodyer; Fraser Fellows; Rennian Wang
Journal:  Int J Biochem Cell Biol       Date:  2005-09-15       Impact factor: 5.085

7.  Effects of certain growth factors on in vitro maturation of rat fetal islet-like structures.

Authors:  C Oberg-Welsh; M Welsh
Journal:  Pancreas       Date:  1996-05       Impact factor: 3.327

8.  Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating.

Authors:  S Perl; J A Kushner; B A Buchholz; A K Meeker; G M Stein; M Hsieh; M Kirby; S Pechhold; E H Liu; D M Harlan; J F Tisdale
Journal:  J Clin Endocrinol Metab       Date:  2010-07-21       Impact factor: 5.958

9.  Characterization of c-Kit and nestin expression during islet cell development in the prenatal and postnatal rat pancreas.

Authors:  Nina Kaur Yashpal; Jinming Li; Rennian Wang
Journal:  Dev Dyn       Date:  2004-04       Impact factor: 3.780

10.  β-cell-specific gene repression: a mechanism to protect against inappropriate or maladjusted insulin secretion?

Authors:  Frans Schuit; Leentje Van Lommel; Mikaela Granvik; Lotte Goyvaerts; Geoffroy de Faudeur; Anica Schraenen; Katleen Lemaire
Journal:  Diabetes       Date:  2012-05       Impact factor: 9.461
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  1 in total

Review 1.  A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase.

Authors:  Zhi-Chao Feng; Matthew Riopel; Alex Popell; Rennian Wang
Journal:  Diabetologia       Date:  2015-02-03       Impact factor: 10.122
  1 in total

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