UNLABELLED: It has been suggested that a reduced HDL particle size could be another feature of the atherogenic dyslipidemia found among viscerally obese subjects. OBJECTIVE: To investigate, in women, the relationship between HDL particle size and coronary artery disease (CAD). METHODS: Average HDL particle size was measured in a sample of 239 women on whom CAD was assessed by angiography. RESULTS: Overall, women who had CAD were characterized by a deteriorated fasting metabolic risk profile, which was accompanied by smaller HDL particles compared to women without CAD (80.4 ± 2.2 Å vs. 81.5 ± 2.7 Å, p < 0.01). In addition, a reduced HDL particle size was a significant correlate of several features of the atherogenic metabolic profile of abdominal obesity such as increased triglyceride and apolipoprotein B concentrations, decreased HDL cholesterol levels, an elevated cholesterol/HDL cholesterol ratio and hyperinsulinemia and was also associated with an increased waist circumference (0.13≤|r|≤0.21, p < 0.05). Odds ratio of being affected by CAD was increased by 2.5-fold (95% CI: 1.4-4.5; p < 0.01) among women with smaller HDL particles compared to women with larger HDL particles. Finally, women characterized by the presence of the NCEP-ATP III clinical criteria or by hypertriglyceridemic waist were characterized by smaller HDL particles compared to women without these clinical phenotypes (p < 0.05). CONCLUSION: HDL particle size appears to be another relevant feature of a dysmetabolic state which is related to CAD risk in women.
UNLABELLED: It has been suggested that a reduced HDL particle size could be another feature of the atherogenic dyslipidemia found among viscerally obese subjects. OBJECTIVE: To investigate, in women, the relationship between HDL particle size and coronary artery disease (CAD). METHODS: Average HDL particle size was measured in a sample of 239 women on whom CAD was assessed by angiography. RESULTS: Overall, women who had CAD were characterized by a deteriorated fasting metabolic risk profile, which was accompanied by smaller HDL particles compared to women without CAD (80.4 ± 2.2 Å vs. 81.5 ± 2.7 Å, p < 0.01). In addition, a reduced HDL particle size was a significant correlate of several features of the atherogenic metabolic profile of abdominal obesity such as increased triglyceride and apolipoprotein B concentrations, decreased HDL cholesterol levels, an elevated cholesterol/HDL cholesterol ratio and hyperinsulinemia and was also associated with an increased waist circumference (0.13≤|r|≤0.21, p < 0.05). Odds ratio of being affected by CAD was increased by 2.5-fold (95% CI: 1.4-4.5; p < 0.01) among women with smaller HDL particles compared to women with larger HDL particles. Finally, women characterized by the presence of the NCEP-ATP III clinical criteria or by hypertriglyceridemic waist were characterized by smaller HDL particles compared to women without these clinical phenotypes (p < 0.05). CONCLUSION: HDL particle size appears to be another relevant feature of a dysmetabolic state which is related to CAD risk in women.
Authors: Konstantin A Krychtiuk; Stefan P Kastl; Stefan Pfaffenberger; Thomas Pongratz; Sebastian L Hofbauer; Anna Wonnerth; Katharina M Katsaros; Georg Goliasch; Ludovit Gaspar; Kurt Huber; Gerald Maurer; Elisabeth Dostal; Stanislav Oravec; Johann Wojta; Walter S Speidl Journal: Atherosclerosis Date: 2014-10-18 Impact factor: 5.162
Authors: Sophia Metz; Nikolaj T Krarup; Thomas Bryrup; Julie Støy; Ehm A Andersson; Christina Christoffersen; Matt J Neville; Malene R Christiansen; Anna E Jonsson; Daniel R Witte; Ulla Kampmann; Lars B Nielsen; Niklas R Jørgensen; Fredrik Karpe; Niels Grarup; Oluf Pedersen; Tuomas O Kilpeläinen; Torben Hansen Journal: J Endocr Soc Date: 2022-03-04