Literature DB >> 22695514

External aortic root support for the Marfan aorta: anatomically normal coronary orifices imaged seven years after surgery.

Carlo DiMario1, John Pepper, Tal Golesworthy, Tom Treasure.   

Abstract

The occurrence of angina necessitated investigation of a patient seven years after an operation to protect his dilated Marfan aorta. The customized support, manufactured by a process of computer-aided design, had been fitted in May 2004 when the aortic root measured 49 mm. The magnetic resonance imaging appearances of the aorta remained unchanged over a postoperative period of 7 years and he remained completely well until he began to experience exercise-related angina in 2011. Coronary angiography showed the cause of angina to be an atherosclerotic left anterior descending coronary artery stenosis which was successfully stented. Aortography and coronary angiography performed at that time showed widely patent coronary orifices with no sign of impingement of the external support on the smooth lumen of his coronary arteries. The soft pliant nature of the textile from which the support was made, its intimate fit to the aorta and porous nature allowing incorporation into the aortic adventitia were deliberately built into the design. Nevertheless it was affirming to see these features realized on imaging seven years later. The patient is again completely well and angina free. He is one of a consecutive series of 30 patients who have had this device. There have been no device-related events in over 100 patient/years of follow-up, and all the patients remain alive and well.

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Mesh:

Year:  2012        PMID: 22695514      PMCID: PMC3422948          DOI: 10.1093/icvts/ivs237

Source DB:  PubMed          Journal:  Interact Cardiovasc Thorac Surg        ISSN: 1569-9285


  5 in total

1.  External aortic root support: NICE guidance.

Authors:  Tom Treasure; John Pepper; Tal Golesworthy; Raad Mohiaddin; Robert H Anderson
Journal:  Heart       Date:  2011-10-14       Impact factor: 5.994

2.  Manufacturing and placing a bespoke support for the Marfan aortic root: description of the method and technical results and status at one year for the first ten patients.

Authors:  John Pepper; Tal Golesworthy; Martin Utley; John Chan; Skandadas Ganeshalingam; Michael Lamperth; Raad Mohiaddin; Tom Treasure
Journal:  Interact Cardiovasc Thorac Surg       Date:  2009-12-11

Review 3.  Surgical management of aortic root disease in Marfan syndrome: a systematic review and meta-analysis.

Authors:  Umberto Benedetto; Giovanni Melina; Johanna J M Takkenberg; Antonino Roscitano; Emiliano Angeloni; Riccardo Sinatra
Journal:  Heart       Date:  2011-01-12       Impact factor: 5.994

4.  Aortic regurgitation after valve-sparing aortic root replacement: modes of failure.

Authors:  Takanori Oka; Yutaka Okita; Masamichi Matsumori; Kenji Okada; Hitoshi Minami; Hiroshi Munakata; Takeshi Inoue; Akiko Tanaka; Toshihito Sakamoto; Atsushi Omura; Takuo Nomura
Journal:  Ann Thorac Surg       Date:  2011-09-25       Impact factor: 4.330

5.  A method for early evaluation of a recently introduced technology by deriving a comparative group from existing clinical data: a case study in external support of the Marfan aortic root.

Authors:  Tom Treasure; Sonya Crowe; K M John Chan; Aaron Ranasinghe; Rizwan Attia; Belinda Lees; Martin Utley; Tal Golesworthy; John Pepper
Journal:  BMJ Open       Date:  2012-03-02       Impact factor: 2.692

  5 in total
  1 in total

1.  Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1-9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement.

Authors:  Tom Treasure; Johanna J M Takkenberg; Tal Golesworthy; Filip Rega; Mario Petrou; Ulrich Rosendahl; Raad Mohiaddin; Michael Rubens; Warren Thornton; Belinda Lees; John Pepper
Journal:  Heart       Date:  2014-01-06       Impact factor: 5.994

  1 in total

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