Hyuma Makizako1, Takehiko Doi, Hiroyuki Shimada, Daisuke Yoshida, Yuko Takayama, Takao Suzuki. 1. Department for Research and Development to Support Independent Life of Elderly, Center for Gerontology and Social Science National Institute of Longevity Science, National Center for Geriatrics and Gerontology, Aichi, Japan. makizako@ncgg.go.jp
Abstract
AIM: The aim of this study was to examine the relationship between dual-task performance and neurocognitive measures in community-dwelling older people with mild cognitive impairment (MCI). METHODS: A total of 98 subjects (mean age 74.8 years, 52.0% female) participated in the study. We compared 36 participants with amnestic MCI (aMCI) with 62 participants with non-amnestic MCI (non-aMCI) on dual-task performance as measured by reaction time responses. The relationships between dual-task performance and multiple domains of neurocognitive functions, including general cognitive function, visual memory, working memory, executive function and processing speed, were examined. RESULTS: Although there were no statistically significant group differences in simple reaction times (P = 0.734), the aMCI group showed significantly slower dual-task reaction times than the non-aMCI group (P = 0.012). Using multiple regression analysis, we found that there was a significant relationship between executive function and dual-task reaction times (β = 0.298, P = 0.006). CONCLUSION: These results showed that aMCI subjects showed a specific deficit in dual-task performance compared with non-aMCI subjects, and poor dual-task performance was associated with declines in executive function in older people with MCI. Future longitudinal and interventional studies should investigate the use of dual-task testing with varying levels of cognitive demand in older adults at risk of dementia.
AIM: The aim of this study was to examine the relationship between dual-task performance and neurocognitive measures in community-dwelling older people with mild cognitive impairment (MCI). METHODS: A total of 98 subjects (mean age 74.8 years, 52.0% female) participated in the study. We compared 36 participants with amnestic MCI (aMCI) with 62 participants with non-amnestic MCI (non-aMCI) on dual-task performance as measured by reaction time responses. The relationships between dual-task performance and multiple domains of neurocognitive functions, including general cognitive function, visual memory, working memory, executive function and processing speed, were examined. RESULTS: Although there were no statistically significant group differences in simple reaction times (P = 0.734), the aMCI group showed significantly slower dual-task reaction times than the non-aMCI group (P = 0.012). Using multiple regression analysis, we found that there was a significant relationship between executive function and dual-task reaction times (β = 0.298, P = 0.006). CONCLUSION: These results showed that aMCI subjects showed a specific deficit in dual-task performance compared with non-aMCI subjects, and poor dual-task performance was associated with declines in executive function in older people with MCI. Future longitudinal and interventional studies should investigate the use of dual-task testing with varying levels of cognitive demand in older adults at risk of dementia.
Authors: Theodore J Huppert; Helmet Karim; Chia-Cheng Lin; Bader A Alqahtani; Susan L Greenspan; Patrick J Sparto Journal: PLoS One Date: 2017-10-12 Impact factor: 3.240