Literature DB >> 22693302

Lamotrigine-induced toxic epidermal necrolysis in a young epileptic.

Fayaz A Sofi1, Parvaiz A Koul, Showkat A Mufti, G N Dhobi.   

Abstract

A 20-year-old young female presented with extensive skin rashes with bullae and extensive epidermal necrolysis about 20 days after the addition of lamotrigine (LTG) to her anticonvulsant medication. The patient was managed by stopping LTG and supportive treatment. The seizures were controlled with increase in the doses of carbamazepine. The report emphasises exercising of caution once LTG is added to a regimen containing valproic acid.

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Year:  2011        PMID： 22693302      PMCID： PMC3132628          DOI： 10.1136/bcr.04.2011.4149

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  24 in total

Review 1.  Stevens-Johnson syndrome and toxic epidermal necrolysis-challenges of recognition and management.

Authors:  S P Sane; A D Bhatt
Journal:  J Assoc Physicians India       Date:  2000-10

Review 2.  Pathogenesis and recent therapeutic trends in Stevens-Johnson syndrome and toxic epidermal necrolysis.

Authors:  Barzin Khalili; Sami L Bahna
Journal:  Ann Allergy Asthma Immunol       Date:  2006-09       Impact factor: 6.347

3.  [Lyell syndrome associated with lamotrigine].

Authors:  C Fernández-Calvo; J Olascoaga; A Resano; J Urcola; A Tuneu; J Zubizarreta
Journal:  Rev Neurol       Date:  2000 Dec 16-31       Impact factor: 0.870

4.  Clinical manifestations and outcomes in 17 cases of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Authors:  K C Wong; P J Kennedy; S Lee
Journal:  Australas J Dermatol       Date:  1999-08       Impact factor: 2.875

5.  Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid.

Authors:  B Yalçin; A Karaduman
Journal:  J Am Acad Dermatol       Date:  2000-11       Impact factor: 11.527

6.  Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death?

Authors:  I Garcia-Doval; L LeCleach; H Bocquet; X L Otero; J C Roujeau
Journal:  Arch Dermatol       Date:  2000-03

7.  Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis.

Authors:  J C Roujeau; J P Kelly; L Naldi; B Rzany; R S Stern; T Anderson; A Auquier; S Bastuji-Garin; O Correia; F Locati
Journal:  N Engl J Med       Date:  1995-12-14       Impact factor: 91.245

Review 8.  Use of intravenous immunoglobulin in children with stevens-johnson syndrome and toxic epidermal necrolysis: seven cases and review of the literature.

Authors:  Denise W Metry; Peter Jung; Moise L Levy
Journal:  Pediatrics       Date:  2003-12       Impact factor: 7.124

Review 9.  Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management.

Authors:  Joseph R Calabrese; John R Sullivan; Charles L Bowden; Trisha Suppes; Joseph F Goldberg; Gary S Sachs; Melvin D Shelton; Frederick K Goodwin; Mark A Frye; Vivek Kusumakar
Journal:  J Clin Psychiatry       Date:  2002-11       Impact factor: 4.384

10.  Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action.

Authors:  M J Leach; C M Marden; A A Miller
Journal:  Epilepsia       Date:  1986 Sep-Oct       Impact factor: 5.864
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