Literature DB >> 22693038

Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia.

Sue Richards1, Ching-Hon Pui, Paul Gayon.   

Abstract

Treatment of the central nervous system (CNS) is an essential therapy component for childhood acute lymphoblastic leukemia (ALL). Individual patient data from 47 trials addressing 16 CNS treatment comparisons were analyzed. Event-free survival (EFS) was similar for radiotherapy versus intrathecal (IT), and radiotherapy plus IT versus IV methotrexate (IV MTX) plus IT. Triple intrathecal therapy (TIT) gave similar EFS but poorer survival than intrathecal methotrexate (IT MTX), but additional IV MTX improved both outcomes. One trial resulted in similar EFS and survival with IV MTX plus IT MTX versus TIT alone. Radiotherapy can generally be replaced by IT therapy. TIT should be used with effective systemic therapy such as IV MTX.
Copyright © 2012 Wiley Periodicals, Inc.

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Year:  2012        PMID： 22693038      PMCID： PMC3461084          DOI： 10.1002/pbc.24228

Source DB:  PubMed          Journal:  Pediatr Blood Cancer        ISSN： 1545-5009            Impact factor:   3.167


  57 in total

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Journal:  Cancer       Date:  1989-01-01       Impact factor: 6.860

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Authors:  F Sackmann Muriel; S Pavlovsky; J A Peñalver; G Hidalgo; A Cebrian Bonesana; M Eppinger-Helft; G H De Macchi; A Pavlovsky
Journal:  Cancer       Date:  1974-08       Impact factor: 6.860

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Review 7.  Current management and challenges of malignant disease in the CNS in paediatric leukaemia.

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Journal:  Eur J Cancer       Date:  1991       Impact factor: 9.162

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  23 in total

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3.  Evaluation of Biomarkers of Oxidative Stress and Apoptosis in Patients With Severe Methotrexate Neurotoxicity: A Case Series.

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