| Literature DB >> 22692092 |
Elizabeth L Yanik1, Sonia Napravnik, Christopher B Hurt, Ann Dennis, E Byrd Quinlivan, Joe Sebastian, Joann D Kuruc, Joseph J Eron.
Abstract
The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.Entities:
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Year: 2012 PMID: 22692092 PMCID: PMC3458150 DOI: 10.1097/QAI.0b013e3182618f05
Source DB: PubMed Journal: J Acquir Immune Defic Syndr ISSN: 1525-4135 Impact factor: 3.731