Literature DB >> 22692002

Emerging role of autophagy in kidney function, diseases and aging.

Tobias B Huber1, Charles L Edelstein, Björn Hartleben, Ken Inoki, Man Jiang, Daisuke Koya, Shinji Kume, Wilfred Lieberthal, Nicolas Pallet, Alejandro Quiroga, Kameswaran Ravichandran, Katalin Susztak, Sei Yoshida, Zheng Dong.   

Abstract

Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.

Entities:  

Keywords:  acute kidney injury; aging; autophagy; glomerulus; kidney; kidney transplantation; mTOR; podocyte; polycystic kidney disease

Mesh：

Year:  2012        PMID： 22692002      PMCID： PMC3429540          DOI： 10.4161/auto.19821

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  267 in total

Review 1.  Recent advances in the pathophysiology of ischemic acute renal failure.

Authors:  Joseph V Bonventre; Joel M Weinberg
Journal:  J Am Soc Nephrol       Date:  2003-08       Impact factor: 10.121

2.  Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.

Authors:  Ariel F Castro; John F Rebhun; Geoffrey J Clark; Lawrence A Quilliam
Journal:  J Biol Chem       Date:  2003-07-03       Impact factor: 5.157

3.  Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

Authors:  Ken Inoki; Yong Li; Tian Xu; Kun-Liang Guan
Journal:  Genes Dev       Date:  2003-07-17       Impact factor: 11.361

4.  The natural history of chronic allograft nephropathy.

Authors:  Brian J Nankivell; Richard J Borrows; Caroline L-S Fung; Philip J O'Connell; Richard D M Allen; Jeremy R Chapman
Journal:  N Engl J Med       Date:  2003-12-11       Impact factor: 91.245

5.  Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.

Authors:  Yong Zhang; Xinsheng Gao; Leslie J Saucedo; Binggen Ru; Bruce A Edgar; Duojia Pan
Journal:  Nat Cell Biol       Date:  2003-06       Impact factor: 28.824

6.  Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

Authors:  Attila Garami; Fried J T Zwartkruis; Takahiro Nobukuni; Manel Joaquin; Marta Roccio; Hugo Stocker; Sara C Kozma; Ernst Hafen; Johannes L Bos; George Thomas
Journal:  Mol Cell       Date:  2003-06       Impact factor: 17.970

7.  In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.

Authors:  Noboru Mizushima; Akitsugu Yamamoto; Makoto Matsui; Tamotsu Yoshimori; Yoshinori Ohsumi
Journal:  Mol Biol Cell       Date:  2003-12-29       Impact factor: 4.138

8.  Autophagy genes are essential for dauer development and life-span extension in C. elegans.

Authors:  Alicia Meléndez; Zsolt Tallóczy; Matthew Seaman; Eeva-Liisa Eskelinen; David H Hall; Beth Levine
Journal:  Science       Date:  2003-09-05       Impact factor: 47.728

9.  Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

Authors:  He-Jin Lee; Farnaz Khoshaghideh; Smita Patel; Seung-Jae Lee
Journal:  J Neurosci       Date:  2004-02-25       Impact factor: 6.167

10.  Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Authors:  Andrew R Tee; Brendan D Manning; Philippe P Roux; Lewis C Cantley; John Blenis
Journal:  Curr Biol       Date:  2003-08-05       Impact factor: 10.834
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  117 in total

Review 1.  Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors.

Authors:  Ralph A DeFronzo; W Brian Reeves; Alaa S Awad
Journal:  Nat Rev Nephrol       Date:  2021-02-05       Impact factor: 28.314

2.  TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway.

Authors:  Seong-Yeon Bae; Sanguine Byun; Soo Han Bae; Do Sik Min; Hyun Ae Woo; Kyunglim Lee
Journal:  Autophagy       Date:  2017-02-15       Impact factor: 16.016

Review 3.  Autophagy and metabolic changes in obesity-related chronic kidney disease.

Authors:  Joseph Satriano; Kumar Sharma
Journal:  Nephrol Dial Transplant       Date:  2013-07-30       Impact factor: 5.992

Review 4.  New insights into the pathology of podocyte loss: mitotic catastrophe.

Authors:  Helen Liapis; Paola Romagnani; Hans-Joachim Anders
Journal:  Am J Pathol       Date:  2013-09-03       Impact factor: 4.307

5.  Proximal tubules forget "self-eating" when they meet Western meals.

Authors:  Ken Inoki
Journal:  J Am Soc Nephrol       Date:  2013-10-03       Impact factor: 10.121

Review 6.  Interventions against nutrient-sensing pathways represent an emerging new therapeutic approach for diabetic nephropathy.

Authors:  Daisuke Koya; Munehiro Kitada; Shinji Kume; Keizo Kanasaki
Journal:  Clin Exp Nephrol       Date:  2013-11-14       Impact factor: 2.801

7.  Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis.

Authors:  Xianghong Zhang; Du Yuan; Qian Sun; Li Xu; Emma Lee; Anthony J Lewis; Brian S Zuckerbraun; Matthew R Rosengart
Journal:  FASEB J       Date:  2017-06-14       Impact factor: 5.191

8.  Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways.

Authors:  Shixuan Wang; Man J Livingston; Yunchao Su; Zheng Dong
Journal:  Autophagy       Date:  2015-04-03       Impact factor: 16.016

9.  Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho.

Authors:  Peng Li; Mingjun Shi; Jenny Maique; Joy Shaffer; Shirley Yan; Orson W Moe; Ming Chang Hu
Journal:  Am J Physiol Renal Physiol       Date:  2020-01-27

10.  CaMKIV regulates mitochondrial dynamics during sepsis.

Authors:  Xianghong Zhang; John E Griepentrog; Baobo Zou; Li Xu; Anthony R Cyr; Lauran M Chambers; Brian S Zuckerbraun; Sruti Shiva; Matthew R Rosengart
Journal:  Cell Calcium       Date:  2020-09-05       Impact factor: 6.817
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