BACKGROUND: Clinical significance of sex hormone receptors in gallbladder cancer is not yet established. This study was performed to assess the expression pattern of estrogen and progesterone receptors in benign and malignant gallbladder lesions, and to assess their clinicopathological significance. METHODS: Tissue samples from resected gallbladder for cholelithiasis (n = 20) and carcinoma gallbladder (n = 25) were evaluated for estrogen and progesterone receptor (ER, PR) expression by automated immunohistochemistry. Their expression was correlated with different clinicopathological parameters. RESULTS: ER expression was significantly high (28%, 95% confidence interval [CI], 14-47) in gallbladder cancer than in chronic cholecystitis (0%; P = .012). PR expression did not differ in two groups (benign 40%, 95% CI, 21.8-61.4; malignant 52%, 95% CI, 33.5-69.9). Metaplastic benign lesions had near significant higher expression of PR (71.4%) than nonmetaplastic lesion (15.9%; P = .062). Their expression did not correlate with gender, age, menopausal status, presence of gallstones, tumor differentiation, and tumor stage. CONCLUSION: Female sex hormones play an important role in the gallbladder carcinogenesis. ER and PR may not have prognostic value. Presence of ER in ∼1/3 and PR in 1/2 of patients with carcinoma gallbladder suggests the potential role of antihormonal therapy.
BACKGROUND: Clinical significance of sex hormone receptors in gallbladder cancer is not yet established. This study was performed to assess the expression pattern of estrogen and progesterone receptors in benign and malignant gallbladder lesions, and to assess their clinicopathological significance. METHODS: Tissue samples from resected gallbladder for cholelithiasis (n = 20) and carcinoma gallbladder (n = 25) were evaluated for estrogen and progesterone receptor (ER, PR) expression by automated immunohistochemistry. Their expression was correlated with different clinicopathological parameters. RESULTS: ER expression was significantly high (28%, 95% confidence interval [CI], 14-47) in gallbladder cancer than in chronic cholecystitis (0%; P = .012). PR expression did not differ in two groups (benign 40%, 95% CI, 21.8-61.4; malignant 52%, 95% CI, 33.5-69.9). Metaplastic benign lesions had near significant higher expression of PR (71.4%) than nonmetaplastic lesion (15.9%; P = .062). Their expression did not correlate with gender, age, menopausal status, presence of gallstones, tumor differentiation, and tumor stage. CONCLUSION: Female sex hormones play an important role in the gallbladder carcinogenesis. ER and PR may not have prognostic value. Presence of ER in ∼1/3 and PR in 1/2 of patients with carcinoma gallbladder suggests the potential role of antihormonal therapy.
Authors: Sarah S Jackson; Hans-Olov Adami; Gabriella Andreotti; Laura E Beane-Freeman; Amy Berrington de González; Julie E Buring; Gary E Fraser; Neal D Freedman; Susan M Gapstur; Gretchen Gierach; Graham G Giles; Francine Grodstein; Patricia Hartge; Mazda Jenab; Victoria Kirsh; Synnove F Knutsen; Qing Lan; Susanna C Larsson; I-Min Lee; Mei-Hsuan Lee; Linda M Liao; Roger L Milne; Kristine R Monroe; Marian L Neuhouser; Katie M O'Brien; Jessica L Petrick; Mark P Purdue; Thomas E Rohan; Sven Sandin; Dale P Sandler; Norie Sawada; Aladdin H Shadyab; Tracey G Simon; Rashmi Sinha; Rachael Stolzenberg-Solomon; Shoichiro Tsugane; Elisabete Weiderpass; Alicja Wolk; Hwai-I Yang; Wei Zheng; Katherine A McGlynn; Peter T Campbell; Jill Koshiol Journal: J Hepatol Date: 2020-05-11 Impact factor: 25.083
Authors: Jun Ho Yi; In-Gu Do; Jiryeon Jang; Seung Tae Kim; Kyoung-Mee Kim; Se Hoon Park; Joon Oh Park; Young Suk Park; Ho Yeong Lim; Won Ki Kang; Jeeyun Lee Journal: Sci Rep Date: 2014-12-23 Impact factor: 4.379