Literature DB >> 226900

Influence of theophylline on concentrations of cyclic 3',5'-adenosine monophosphate and cyclic 3',5'-guanosine monophosphate of rat brain.

V Stefanovich.   

Abstract

The influence of theophylline (2.5--100 mg/kg p.o.) on cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5'-guanosine monophosphate (cGMP) in brain of Sprague-Dawley rats (0.5--3.0 hr after administration of theophylline) was investigated. It was found that theophylline increases cAMP and cGMP levels when administered in a dose of 25 mg/kg or higher. A significant decrease of cGMP level was observed after administration of 10 mg/kg. The results of this study suggest that the influence of theophylline on cyclic nucleotide levels of rat brain is the result of two factors: (a) inhibitory properties of theophylline on cAMP and cGMP phosphodiesterases and (b) competition of theophylline with adenosine.

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Year:  1979        PMID： 226900     DOI： 10.1007/bf00964436

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  8 in total

1.  Cyclic nucleotide phosphodiesterases: properties, activators, inhibitors, structure--activity relationships, and possible role in drug development.

Authors:  M Samir Amer; W E Kreighbaum
Journal:  J Pharm Sci       Date:  1975-01       Impact factor: 3.534

2.  Adenosine-dependent formation of cyclic AMP in brain slices.

Authors:  H D Mah; J W Daly
Journal:  Pharmacol Res Commun       Date:  1976-02

3.  Elevation of cyclic AMP in C-1300 murine neuroblastoma by adenosine and related compounds and the antagonism of this response by methylxanthines.

Authors:  R D Green; L R Stanberry
Journal:  Biochem Pharmacol       Date:  1977-01-01       Impact factor: 5.858

4.  The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.

Authors:  A Sattin; T W Rall
Journal:  Mol Pharmacol       Date:  1970-01       Impact factor: 4.436

5.  Freeze-blowing: a new technique for the study of brain in vivo.

Authors:  R L Veech; R L Harris; D Veloso; E H Veech
Journal:  J Neurochem       Date:  1973-01       Impact factor: 5.372

6.  Cyclic adenosine monophosphate in cerebral cortex. Alterations following trauma.

Authors:  H Watanabe; J V Passonneau
Journal:  Arch Neurol       Date:  1975-03

7.  Differential inhibition of phosphodiesterase according to the organ origin of the enzyme.

Authors:  P Uzunov; V Petkov; S Stancheva
Journal:  Acta Neurobiol Exp (Wars)       Date:  1975       Impact factor: 1.579

8.  Cyclid 3':5'-nucleotide phosphodiesterase. Interconvertible multiple forms and their effects on enzyme activity and kinetics.

Authors:  A L Pichard; W Y Cheung
Journal:  J Biol Chem       Date:  1976-09-25       Impact factor: 5.157
  8 in total
  2 in total

1.  Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3', 5'-monophosphate phosphodiesterase inhibitors.

Authors:  H Wachtel
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

2.  Glucose starvation-induced dispersal of Pseudomonas aeruginosa biofilms is cAMP and energy dependent.

Authors:  Tran T Huynh; Diane McDougald; Janosch Klebensberger; Budoor Al Qarni; Nicolas Barraud; Scott A Rice; Staffan Kjelleberg; David Schleheck
Journal:  PLoS One       Date:  2012-08-14       Impact factor: 3.240
  2 in total

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