Literature DB >> 22689790

Hedgehog signaling and maintenance of homeostasis in the intestinal epithelium.

Nikè V J A Büller1, Sanne L Rosekrans, Jessica Westerlund, Gijs R van den Brink.   

Abstract

Homeostasis of the rapidly renewing intestinal epithelium depends on a balance between cell proliferation and loss. Indian hedgehog (Ihh) acts as a negative feedback signal in this dynamic equilibrium. We discuss recent evidence that Ihh may be one of the key epithelial signals that indicates epithelial integrity to the underlying mesenchyme.

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Year:  2012        PMID： 22689790     DOI： 10.1152/physiol.00003.2012

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  27 in total

Review 1.  Mesenchymal-epithelial interactions during digestive tract development and epithelial stem cell regeneration.

Authors:  Ludovic Le Guen; Stéphane Marchal; Sandrine Faure; Pascal de Santa Barbara
Journal:  Cell Mol Life Sci       Date:  2015-07-01       Impact factor: 9.261

2.  Gene expression profile of endothelial cells during perturbation of the gut vascular barrier.

Authors:  Ilaria Spadoni; Alessandro Pietrelli; Graziano Pesole; Maria Rescigno
Journal:  Gut Microbes       Date:  2016-10-10

3.  The ubiquitin ligase ITCH coordinates small intestinal epithelial homeostasis by modulating cell proliferation, differentiation, and migration.

Authors:  Heather L Mentrup; Amanda Hartman; Elizabeth L Thames; Wassim A Basheer; Lydia E Matesic
Journal:  Differentiation       Date:  2017-12-15       Impact factor: 3.880

4.  Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling.

Authors:  Alessandra V de S Faria; Adamu Ishaku Akyala; Kaushal Parikh; Lois W Brüggemann; C Arnold Spek; Wanlu Cao; Marco J Bruno; Maarten F Bijlsma; Gwenny M Fuhler; Maikel P Peppelenbosch
Journal:  J Biol Chem       Date:  2019-04-16       Impact factor: 5.157

5.  Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation.

Authors:  Florien Westendorp; Olga N Karpus; Pim J Koelink; Jacqueline L M Vermeulen; Sander Meisner; Jan Koster; Nikè V J A Büller; Manon E Wildenberg; Vanesa Muncan; Gijs R van den Brink
Journal:  Oncogene       Date:  2021-01-21       Impact factor: 9.867

Review 6.  Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers.

Authors:  Qiang Chen; Kesong Peng; Pingli Mo; Chundong Yu
Journal:  Cancers (Basel)       Date:  2022-06-08       Impact factor: 6.575

7.  A novel population of subepithelial platelet-derived growth factor receptor α-positive cells in the mouse and human colon.

Authors:  Masaaki Kurahashi; Yasuko Nakano; Lauren E Peri; Jared B Townsend; Sean M Ward; Kenton M Sanders
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2013-02-21       Impact factor: 4.052

8.  Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling.

Authors:  Minghui Zhuo; Wenbo Chen; Shaohui Shang; Peng Guo; Kesong Peng; Ming Li; Pingli Mo; Yongyou Zhang; Xingfeng Qiu; Wengang Li; Chundong Yu
Journal:  Oncogene       Date:  2020-02-24       Impact factor: 9.867

9.  Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation.

Authors:  Winnie Y Zou; Sarah E Blutt; Xi-Lei Zeng; Min-Shan Chen; Yuan-Hung Lo; David Castillo-Azofeifa; Ophir D Klein; Noah F Shroyer; Mark Donowitz; Mary K Estes
Journal:  Cell Rep       Date:  2018-01-28       Impact factor: 9.995

10.  Debra-mediated Ci degradation controls tissue homeostasis in Drosophila adult midgut.

Authors:  Zhouhua Li; Yueqin Guo; Lili Han; Yan Zhang; Lai Shi; Xudong Huang; Xinhua Lin
Journal:  Stem Cell Reports       Date:  2014-01-30       Impact factor: 7.765
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