Literature DB >> 22689411

Chemical probes for the recognition of cannabinoid receptors in native systems.

Lidia Martín-Couce1, Mar Martín-Fontecha, Oscar Palomares, Leyre Mestre, Arnau Cordomí, Miriam Hernangomez, Sara Palma, Leonardo Pardo, Carmen Guaza, María L López-Rodríguez, Silvia Ortega-Gutiérrez.   

Abstract

Receptors made visible: The described biotin-tagged small-molecule probes with excellent affinities for the CB(1) and CB(2) cannabinoid receptors (CB(1)R and CB(2)R) enable direct visualization of these receptors in native cellular systems, including neurons, microglia, and immune cells. This method could overcome some of the limitations of current methodologies and may help to dissect the complexity of the endogenous cannabinoid system.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22689411     DOI： 10.1002/anie.201200467

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  6 in total

1.  A cannabinoid link between mitochondria and memory.

Authors:  Etienne Hebert-Chatelain; Tifany Desprez; Román Serrat; Luigi Bellocchio; Edgar Soria-Gomez; Arnau Busquets-Garcia; Antonio Christian Pagano Zottola; Anna Delamarre; Astrid Cannich; Peggy Vincent; Marjorie Varilh; Laurie M Robin; Geoffrey Terral; M Dolores García-Fernández; Michelangelo Colavita; Wilfrid Mazier; Filippo Drago; Nagore Puente; Leire Reguero; Izaskun Elezgarai; Jean-William Dupuy; Daniela Cota; Maria-Luz Lopez-Rodriguez; Gabriel Barreda-Gómez; Federico Massa; Pedro Grandes; Giovanni Bénard; Giovanni Marsicano
Journal:  Nature       Date:  2016-11-09       Impact factor: 49.962

2.  A novel near-infrared fluorescence imaging probe that preferentially binds to cannabinoid receptors CB2R over CB1R.

Authors:  Xiaoxi Ling; Shaojuan Zhang; Pin Shao; Weixia Li; Ling Yang; Ying Ding; Cong Xu; Nephi Stella; Mingfeng Bai
Journal:  Biomaterials       Date:  2015-04-28       Impact factor: 12.479

3.  A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration.

Authors:  Inés González-Gil; Debora Zian; Henar Vázquez-Villa; Gloria Hernández-Torres; R Fernando Martínez; Nora Khiar-Fernández; Richard Rivera; Yasuyuki Kihara; Isabel Devesa; Sakthikumar Mathivanan; Cristina Rosell Del Valle; Emma Zambrana-Infantes; María Puigdomenech; Giovanni Cincilla; Melchor Sanchez-Martinez; Fernando Rodríguez de Fonseca; Antonio V Ferrer-Montiel; Jerold Chun; Rubén López-Vales; María L López-Rodríguez; Silvia Ortega-Gutiérrez
Journal:  J Med Chem       Date:  2019-12-16       Impact factor: 7.446

4.  Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay.

Authors:  Agostino Bruno; Francesca Lembo; Ettore Novellino; Mariano Stornaiuolo; Luciana Marinelli
Journal:  Sci Rep       Date:  2014-01-20       Impact factor: 4.379

5.  Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.

Authors:  Marjolein Soethoudt; Sara C Stolze; Matthias V Westphal; Luuk van Stralen; Andrea Martella; Eva J van Rooden; Wolfgang Guba; Zoltan V Varga; Hui Deng; Sander I van Kasteren; Uwe Grether; Adriaan P IJzerman; Pal Pacher; Erick M Carreira; Herman S Overkleeft; Andreea Ioan-Facsinay; Laura H Heitman; Mario van der Stelt
Journal:  J Am Chem Soc       Date:  2018-02-16       Impact factor: 15.419

Review 6.  Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes.

Authors:  Filippo Basagni; Michela Rosini; Michael Decker
Journal:  ChemMedChem       Date:  2020-06-24       Impact factor: 3.466
  6 in total

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