BACKGROUND: Greater height has been associated with increased risk of several cancers, but epidemiological data on height and pancreatic cancer are inconclusive. We conducted a systematic review and meta-analysis of prospective studies to clarify these results. METHODS: PubMed and several other databases were searched up to September 2011. Prospective studies of height and pancreatic cancer were included. Summary relative risks were estimated by the use of a random effects model. RESULTS: We identified twelve cohort studies that were included in the meta-analysis. The summary RR per 5-cm increase in height was 1.07 (95 % CI: 1.03-1.12, I (2) = 57 %). The results were similar among men and women. The summary estimate was attenuated when we included results from two pooled analyses together with these studies, summary RR = 1.03 (95 % CI: 1.00-1.07, I (2) = 44 %). CONCLUSIONS: This meta-analysis of cohort studies provides further evidence that greater adult attained height is associated with increased pancreatic cancer risk. However, given the unexplained heterogeneity, further studies are needed before a conclusion can be drawn.
BACKGROUND: Greater height has been associated with increased risk of several cancers, but epidemiological data on height and pancreatic cancer are inconclusive. We conducted a systematic review and meta-analysis of prospective studies to clarify these results. METHODS: PubMed and several other databases were searched up to September 2011. Prospective studies of height and pancreatic cancer were included. Summary relative risks were estimated by the use of a random effects model. RESULTS: We identified twelve cohort studies that were included in the meta-analysis. The summary RR per 5-cm increase in height was 1.07 (95 % CI: 1.03-1.12, I (2) = 57 %). The results were similar among men and women. The summary estimate was attenuated when we included results from two pooled analyses together with these studies, summary RR = 1.03 (95 % CI: 1.00-1.07, I (2) = 44 %). CONCLUSIONS: This meta-analysis of cohort studies provides further evidence that greater adult attained height is associated with increased pancreatic cancer risk. However, given the unexplained heterogeneity, further studies are needed before a conclusion can be drawn.
Authors: Yanchang Zhang; Brenda Cartmel; Courtney C Choy; Annette M Molinaro; David J Leffell; Allen E Bale; Susan T Mayne; Leah M Ferrucci Journal: Cancer Epidemiol Date: 2016-12-28 Impact factor: 2.984
Authors: Robert Carreras-Torres; Mattias Johansson; Valerie Gaborieau; Philip C Haycock; Kaitlin H Wade; Caroline L Relton; Richard M Martin; George Davey Smith; Paul Brennan Journal: J Natl Cancer Inst Date: 2017-09-01 Impact factor: 13.506
Authors: Sara Wirén; Christel Häggström; Hanno Ulmer; Jonas Manjer; Tone Bjørge; Gabriele Nagel; Dorthe Johansen; Göran Hallmans; Anders Engeland; Hans Concin; Håkan Jonsson; Randi Selmer; Steinar Tretli; Tanja Stocks; Pär Stattin Journal: Cancer Causes Control Date: 2013-10-31 Impact factor: 2.506
Authors: Leticia Nogueira; Rachael Stolzenberg-Solomon; Michael Gamborg; Thorkild I A Sørensen; Jennifer L Baker Journal: Curr Dev Nutr Date: 2017-09-14