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Literature DB >> 22689222

Molecular engineered super-nanodevices: smart and safe delivery of potent drugs into tumors.

Mingming Ding¹, Jiehua Li, Xueling He, Nijia Song, Hong Tan, Yi Zhang, Lijuan Zhou, Qun Gu, Hua Deng, Qiang Fu.

Abstract

A super-nanodevice engineered at molecular level integrates various desired properties in a smart and coordinated way, and can "switch on" or "turn off" certain functionalities as required. Importantly, it can break through complex physiological barriers, and then precisely ferry potent toxic triptolide into tumor cells in vivo, thus significantly maximizing the therapeutic efficacy and reducing the drug toxicity.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2012 PMID： 22689222 DOI： 10.1002/adma.201200954

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

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Cited

10 in total

1. A highly tunable biocompatible and multifunctional biodegradable elastomer.

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Journal: Adv Mater Date: 2012-12-12 Impact factor: 30.849

2. Precisely synthesized segmented polyurethanes toward block sequence-controlled drug delivery.

Authors: Yuanqing Song; Chuandong Sun; Chenxu Tian; Hao Ming; Yanjun Wang; Wenkai Liu; Nan He; Xueling He; Mingming Ding; Jiehua Li; Feng Luo; Hong Tan; Qiang Fu
Journal: Chem Sci Date: 2022-04-05 Impact factor: 9.969

3. Stimuli-Responsive Programmed Specific Targeting in Nanomedicine.

Authors: Sheng Wang; Peng Huang; Xiaoyuan Chen
Journal: ACS Nano Date: 2016-02-16 Impact factor: 15.881

4. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization.

Authors: Sheng Wang; Peng Huang; Xiaoyuan Chen
Journal: Adv Mater Date: 2016-06-03 Impact factor: 30.849

5. Stable, Bioresponsive, and Macrophage-Evading Polyurethane Micelles Containing an Anionic Tripeptide Chain Extender.

Authors: Danxuan Fang; Menghan Pi; Zhicheng Pan; Nijia Song; Xueling He; Jiehua Li; Feng Luo; Hong Tan; Zhen Li
Journal: ACS Omega Date: 2019-09-27

6. Indoxacarb-Loaded Anionic Polyurethane Blend with Sodium Alginate Improves pH Sensitivity and Ecological Security for Potential Application in Agriculture.

Authors: Shiying Wang; Yi Zhang; Liupeng Yang; Qizhan Zhu; Qianli Ma; Ruifei Wang; Chaoqun Zhang; Zhixiang Zhang
Journal: Polymers (Basel) Date: 2020-05-15 Impact factor: 4.329

Molecular engineered super-nanodevices: smart and safe delivery of potent drugs into tumors.

1. A highly tunable biocompatible and multifunctional biodegradable elastomer.

2. Precisely synthesized segmented polyurethanes toward block sequence-controlled drug delivery.

3. Stimuli-Responsive Programmed Specific Targeting in Nanomedicine.

4. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization.

5. Stable, Bioresponsive, and Macrophage-Evading Polyurethane Micelles Containing an Anionic Tripeptide Chain Extender.

6. Indoxacarb-Loaded Anionic Polyurethane Blend with Sodium Alginate Improves pH Sensitivity and Ecological Security for Potential Application in Agriculture.

7. Crosslinking Induced Reassembly of Multiblock Polymers: Addressing the Dilemma of Stability and Responsivity.

Review 8. Recent advances in functionalized upconversion nanoparticles for light-activated tumor therapy.

9. Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics.

Review 10. The Efficacy of Cholesterol-Based Carriers in Drug Delivery.