Literature DB >> 2268894

62Cu-labeling of human serum albumin-dithiosemicarbazone (HSA-DTS) conjugate for regional plasma volume measurement: application of new 62Zn/62Cu generator system.

Y Fujibayashi1, K Matsumoto, Y Arano, Y Yonekura, J Konishi, A Yokoyama.   

Abstract

62Cu-Labeling of human serum albumin-dithiosemicarbazone (HSA-DTS) conjugate was performed using a newly developed 62Zn/62Cu generator system. HSA-DTS was easily labeled with 62Cu, by simple mixing with 62Cu-generator eluate. In vivo blood clearance of 62Cu-HSA-DTS was similar to 131I-HSA, indicating the high applicability of 62Cu-HSA-DTS as a method for plasma volume measurement. In a positron emission tomography study of a dog, a clear plasma pool image of the head region was obtained.

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Year:  1990        PMID: 2268894     DOI: 10.1248/cpb.38.1946

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  3 in total

1.  Development of a high performance zinc-62/copper-62 radionuclide generator for positron emission tomography.

Authors:  J Zweit; R Goodall; M Cox; J W Babich; G A Potter; H L Sharma; R J Ott
Journal:  Eur J Nucl Med       Date:  1992

2.  Synthesis and characterization of the copper(II) complexes of new N2S2-donor macrocyclic ligands: synthesis and in vivo evaluation of the (64)Cu complexes.

Authors:  Grazia Papini; Simone Alidori; Jason S Lewis; David E Reichert; Maura Pellei; Giancarlo Gioia Lobbia; Gráinne B Biddlecombe; Carolyn J Anderson; Carlo Santini
Journal:  Dalton Trans       Date:  2008-11-04       Impact factor: 4.390

3.  Clinical application of 62Zn/62Cu positron generator: perfusion and plasma pool images in normal subjects.

Authors:  H Okazawa; Y Fujibayashi; Y Yonekura; N Tamaki; S Nishizawa; Y Magata; K Ishizu; T Tsuchida; N Sadato; J Konishi
Journal:  Ann Nucl Med       Date:  1995-05       Impact factor: 2.668

  3 in total

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