Literature DB >> 22688938

Anabolic androgenic steroid induced myocardial toxicity: an evolving problem in an ageing population.

Richard D Rothman1, Rory B Weiner, Harrison Pope, Gen Kanayama, Adolph M Hutter, Michael A Fifer, G William Dec, Aaron L Baggish.   

Abstract

Widespread use of anabolic androgenic steroid (AAS) abuse is a rapidly increasing public health concern with an expanding demographic. Previous studies and reports have been exclusive to young individuals at low risk for traditional, non-AAS associated, cardiovascular disease. To date, the impact of AAS use on older patients has not been well characterised. The patient herein presented documents a dramatic case of an older individual who developed decompensated heart failure secondary to illicit use of AAS, highlighting an evolving problem among a rapidly expanding demographic and illustrating that a) AAS, used to alter appearance or augment performance, is no longer an issue confined to young adults; b) older individuals with ageing myocardium may be particularly susceptible to AAS toxicity and may present with fulminate congestive heart failure; and that c) AAS abstinence coupled with traditional heart failure pharmacotherapy may be an effective treatment for this condition.

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Year:  2011        PMID: 22688938      PMCID: PMC3171059          DOI: 10.1136/bcr.05.2011.4280

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  12 in total

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Review 2.  Anabolics and cardiomyopathy in a bodybuilder: case report and literature review.

Authors:  Christoph Ahlgrim; Maya Guglin
Journal:  J Card Fail       Date:  2009-02-10       Impact factor: 5.712

Review 3.  Performance enhancing drugs (doping agents) and sudden death--a case report and review of the literature.

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Journal:  Int J Legal Med       Date:  1998       Impact factor: 2.686

4.  Abnormal neurovascular control in anabolic androgenic steroids users.

Authors:  Maria Janieire Nazaré Nunes Alves; Marcelo Rodrigues Dos Santos; Rodrigo Gonçalves Dias; César Abreu Akiho; Mateus Camaroti Laterza; Maria Urbana Pinto Brandāo Rondon; Regina Lucia De Moraes Moreau; Carlos Eduardo Negrāo
Journal:  Med Sci Sports Exerc       Date:  2010-05       Impact factor: 5.411

5.  Long-term anabolic-androgenic steroid use is associated with left ventricular dysfunction.

Authors:  Aaron L Baggish; Rory B Weiner; Gen Kanayama; James I Hudson; Michael H Picard; Adolph M Hutter; Harrison G Pope
Journal:  Circ Heart Fail       Date:  2010-04-27       Impact factor: 8.790

6.  Are the cardiac effects of anabolic steroid abuse in strength athletes reversible?

Authors:  A Urhausen; T Albers; W Kindermann
Journal:  Heart       Date:  2004-05       Impact factor: 5.994

7.  High-density-lipoprotein cholesterol in bodybuilders v powerlifters. Negative effects of androgen use.

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Journal:  JAMA       Date:  1984-07-27       Impact factor: 56.272

8.  Raised concentrations of C reactive protein in anabolic steroid using bodybuilders.

Authors:  F M Grace; B Davies
Journal:  Br J Sports Med       Date:  2004-02       Impact factor: 13.800

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Authors:  M K Pesola
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1988

10.  Heart lesions associated with anabolic steroid abuse: comparison of post-mortem findings in athletes and norethandrolone-induced lesions in rabbits.

Authors:  Laurent Fanton; Dalila Belhani; Fanny Vaillant; Alain Tabib; Ludovic Gomez; Jacques Descotes; Leila Dehina; Bernard Bui-Xuan; Daniel Malicier; Quadiri Timour
Journal:  Exp Toxicol Pathol       Date:  2008-11-21
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  4 in total

Review 1.  Comprehensive review of cardiovascular toxicity of drugs and related agents.

Authors:  Přemysl Mladěnka; Lenka Applová; Jiří Patočka; Vera Marisa Costa; Fernando Remiao; Jana Pourová; Aleš Mladěnka; Jana Karlíčková; Luděk Jahodář; Marie Vopršalová; Kurt J Varner; Martin Štěrba
Journal:  Med Res Rev       Date:  2018-01-05       Impact factor: 12.944

Review 2.  Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement.

Authors:  Harrison G Pope; Ruth I Wood; Alan Rogol; Fred Nyberg; Larry Bowers; Shalender Bhasin
Journal:  Endocr Rev       Date:  2013-12-17       Impact factor: 19.871

Review 3.  Anabolic androgenic steroid abuse in the United Kingdom: An update.

Authors:  Carrie Mullen; Benjamin J Whalley; Fabrizio Schifano; Julien S Baker
Journal:  Br J Pharmacol       Date:  2020-03-03       Impact factor: 8.739

Review 4.  Sudden Cardiac Death in Anabolic-Androgenic Steroid Users: A Literature Review.

Authors:  Marco Torrisi; Giuliana Pennisi; Ilenia Russo; Francesco Amico; Massimiliano Esposito; Aldo Liberto; Giuseppe Cocimano; Monica Salerno; Giuseppe Li Rosi; Nunzio Di Nunno; Angelo Montana
Journal:  Medicina (Kaunas)       Date:  2020-11-04       Impact factor: 2.430

  4 in total

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