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Literature DB >> 22688894

A finger on the pulse of Wnt receptor signaling.

Abstract

In a recent issue of Nature, Hao et al. report an unexpected link between the secreted stem cell factor/Wnt agonist R-spondin and Wnt receptors through the transmembrane ZNRF3 protein, a RING finger ubiquitin ligase. ZNRF3 acts to turn over Frizzled and LRP6 receptors. R-spondin binds to ZNRF3, in addition to transmembrane LGR4/5 receptors, to antagonize degradation of the Wnt receptors by ZNRF3, thereby resulting in increased Frizzled and LRP6 levels and a greater Wnt response.

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Year: 2012 PMID： 22688894 PMCID： PMC3463273 DOI： 10.1038/cr.2012.91

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

17 in total

Review 1. Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.

Authors: Nick Barker; Hans Clevers
Journal: Gastroenterology Date: 2010-05 Impact factor: 22.682

Review 2. Wnt/beta-catenin signaling: components, mechanisms, and diseases.

Authors: Bryan T MacDonald; Keiko Tamai; Xi He
Journal: Dev Cell Date: 2009-07 Impact factor: 12.270

3. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

Authors: Wim de Lau; Nick Barker; Teck Y Low; Bon-Kyoung Koo; Vivian S W Li; Hans Teunissen; Pekka Kujala; Andrea Haegebarth; Peter J Peters; Marc van de Wetering; Daniel E Stange; Johan E van Es; Daniele Guardavaccaro; Richard B M Schasfoort; Yasuaki Mohri; Katsuhiko Nishimori; Shabaz Mohammed; Albert J R Heck; Hans Clevers
Journal: Nature Date: 2011-07-04 Impact factor: 49.962

4. R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.

Authors: Qiou Wei; Chika Yokota; Mikhail V Semenov; Brad Doble; Jim Woodgett; Xi He
Journal: J Biol Chem Date: 2007-03-30 Impact factor: 5.157

5. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Authors: Toshiro Sato; Johan H van Es; Hugo J Snippert; Daniel E Stange; Robert G Vries; Maaike van den Born; Nick Barker; Noah F Shroyer; Marc van de Wetering; Hans Clevers
Journal: Nature Date: 2010-11-28 Impact factor: 49.962

6. Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt.

Authors: Akiko Mukai; Miki Yamamoto-Hino; Wakae Awano; Wakako Watanabe; Masayuki Komada; Satoshi Goto
Journal: EMBO J Date: 2010-05-21 Impact factor: 11.598

7. R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.

Authors: Minke E Binnerts; Kyung-Ah Kim; Jessica M Bright; Sejal M Patel; Karolyn Tran; Mei Zhou; John M Leung; Yi Liu; Woodrow E Lomas; Melissa Dixon; Sophie A Hazell; Marie Wagle; Wen-Sheng Nie; Nenad Tomasevic; Jason Williams; Xiaoming Zhan; Michael D Levy; Walter D Funk; Arie Abo
Journal: Proc Natl Acad Sci U S A Date: 2007-09-05 Impact factor: 11.205

8. Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.

Authors: Ju-Suk Nam; Taryn J Turcotte; Peter F Smith; Sangdun Choi; Jeong Kyo Yoon
Journal: J Biol Chem Date: 2006-03-16 Impact factor: 5.157

9. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.

Authors: Olga Kazanskaya; Andrei Glinka; Ivan del Barco Barrantes; Peter Stannek; Christof Niehrs; Wei Wu
Journal: Dev Cell Date: 2004-10 Impact factor: 12.270

10. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Authors: Iris M Heid; Anne U Jackson; Joshua C Randall; Thomas W Winkler; Lu Qi; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; M Carola Zillikens; Elizabeth K Speliotes; Reedik Mägi; Tsegaselassie Workalemahu; Charles C White; Nabila Bouatia-Naji; Tamara B Harris; Sonja I Berndt; Erik Ingelsson; Cristen J Willer; Michael N Weedon; Jian'an Luan; Sailaja Vedantam; Tõnu Esko; Tuomas O Kilpeläinen; Zoltán Kutalik; Shengxu Li; Keri L Monda; Anna L Dixon; Christopher C Holmes; Lee M Kaplan; Liming Liang; Josine L Min; Miriam F Moffatt; Cliona Molony; George Nicholson; Eric E Schadt; Krina T Zondervan; Mary F Feitosa; Teresa Ferreira; Hana Lango Allen; Robert J Weyant; Eleanor Wheeler; Andrew R Wood; Karol Estrada; Michael E Goddard; Guillaume Lettre; Massimo Mangino; Dale R Nyholt; Shaun Purcell; Albert Vernon Smith; Peter M Visscher; Jian Yang; Steven A McCarroll; James Nemesh; Benjamin F Voight; Devin Absher; Najaf Amin; Thor Aspelund; Lachlan Coin; Nicole L Glazer; Caroline Hayward; Nancy L Heard-Costa; Jouke-Jan Hottenga; Asa Johansson; Toby Johnson; Marika Kaakinen; Karen Kapur; Shamika Ketkar; Joshua W Knowles; Peter Kraft; Aldi T Kraja; Claudia Lamina; Michael F Leitzmann; Barbara McKnight; Andrew P Morris; Ken K Ong; John R B Perry; Marjolein J Peters; Ozren Polasek; Inga Prokopenko; Nigel W Rayner; Samuli Ripatti; Fernando Rivadeneira; Neil R Robertson; Serena Sanna; Ulla Sovio; Ida Surakka; Alexander Teumer; Sophie van Wingerden; Veronique Vitart; Jing Hua Zhao; Christine Cavalcanti-Proença; Peter S Chines; Eva Fisher; Jennifer R Kulzer; Cecile Lecoeur; Narisu Narisu; Camilla Sandholt; Laura J Scott; Kaisa Silander; Klaus Stark; Mari-Liis Tammesoo; Tanya M Teslovich; Nicholas John Timpson; Richard M Watanabe; Ryan Welch; Daniel I Chasman; Matthew N Cooper; John-Olov Jansson; Johannes Kettunen; Robert W Lawrence; Niina Pellikka; Markus Perola; Liesbeth Vandenput; Helene Alavere; Peter Almgren; Larry D Atwood; Amanda J Bennett; Reiner Biffar; Lori L Bonnycastle; Stefan R Bornstein; Thomas A Buchanan; Harry Campbell; Ian N M Day; Mariano Dei; Marcus Dörr; Paul Elliott; Michael R Erdos; Johan G Eriksson; Nelson B Freimer; Mao Fu; Stefan Gaget; Eco J C Geus; Anette P Gjesing; Harald Grallert; Jürgen Grässler; Christopher J Groves; Candace Guiducci; Anna-Liisa Hartikainen; Neelam Hassanali; Aki S Havulinna; Karl-Heinz Herzig; Andrew A Hicks; Jennie Hui; Wilmar Igl; Pekka Jousilahti; Antti Jula; Eero Kajantie; Leena Kinnunen; Ivana Kolcic; Seppo Koskinen; Peter Kovacs; Heyo K Kroemer; Vjekoslav Krzelj; Johanna Kuusisto; Kirsti Kvaloy; Jaana Laitinen; Olivier Lantieri; G Mark Lathrop; Marja-Liisa Lokki; Robert N Luben; Barbara Ludwig; Wendy L McArdle; Anne McCarthy; Mario A Morken; Mari Nelis; Matt J Neville; Guillaume Paré; Alex N Parker; John F Peden; Irene Pichler; Kirsi H Pietiläinen; Carl G P Platou; Anneli Pouta; Martin Ridderstråle; Nilesh J Samani; Jouko Saramies; Juha Sinisalo; Jan H Smit; Rona J Strawbridge; Heather M Stringham; Amy J Swift; Maris Teder-Laving; Brian Thomson; Gianluca Usala; Joyce B J van Meurs; Gert-Jan van Ommen; Vincent Vatin; Claudia B Volpato; Henri Wallaschofski; G Bragi Walters; Elisabeth Widen; Sarah H Wild; Gonneke Willemsen; Daniel R Witte; Lina Zgaga; Paavo Zitting; John P Beilby; Alan L James; Mika Kähönen; Terho Lehtimäki; Markku S Nieminen; Claes Ohlsson; Lyle J Palmer; Olli Raitakari; Paul M Ridker; Michael Stumvoll; Anke Tönjes; Jorma Viikari; Beverley Balkau; Yoav Ben-Shlomo; Richard N Bergman; Heiner Boeing; George Davey Smith; Shah Ebrahim; Philippe Froguel; Torben Hansen; Christian Hengstenberg; Kristian Hveem; Bo Isomaa; Torben Jørgensen; Fredrik Karpe; Kay-Tee Khaw; Markku Laakso; Debbie A Lawlor; Michel Marre; Thomas Meitinger; Andres Metspalu; Kristian Midthjell; Oluf Pedersen; Veikko Salomaa; Peter E H Schwarz; Tiinamaija Tuomi; Jaakko Tuomilehto; Timo T Valle; Nicholas J Wareham; Alice M Arnold; Jacques S Beckmann; Sven Bergmann; Eric Boerwinkle; Dorret I Boomsma; Mark J Caulfield; Francis S Collins; Gudny Eiriksdottir; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Andrew T Hattersley; Albert Hofman; Frank B Hu; Thomas Illig; Carlos Iribarren; Marjo-Riitta Jarvelin; W H Linda Kao; Jaakko Kaprio; Lenore J Launer; Patricia B Munroe; Ben Oostra; Brenda W Penninx; Peter P Pramstaller; Bruce M Psaty; Thomas Quertermous; Aila Rissanen; Igor Rudan; Alan R Shuldiner; Nicole Soranzo; Timothy D Spector; Ann-Christine Syvanen; Manuela Uda; André Uitterlinden; Henry Völzke; Peter Vollenweider; James F Wilson; Jacqueline C Witteman; Alan F Wright; Gonçalo R Abecasis; Michael Boehnke; Ingrid B Borecki; Panos Deloukas; Timothy M Frayling; Leif C Groop; Talin Haritunians; David J Hunter; Robert C Kaplan; Kari E North; Jeffrey R O'Connell; Leena Peltonen; David Schlessinger; David P Strachan; Joel N Hirschhorn; Themistocles L Assimes; H-Erich Wichmann; Unnur Thorsteinsdottir; Cornelia M van Duijn; Kari Stefansson; L Adrienne Cupples; Ruth J F Loos; Inês Barroso; Mark I McCarthy; Caroline S Fox; Karen L Mohlke; Cecilia M Lindgren
Journal: Nat Genet Date: 2010-10-10 Impact factor: 38.330

6 in total

1. A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction.

Authors: Mira I Pronobis; Nasser M Rusan; Mark Peifer
Journal: Elife Date: 2015-09-22 Impact factor: 8.140

6. R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/β-catenin signaling in zebrafish embryos.

Authors: Xiaozhi Rong; Chen Chen; Pin Zhou; Yumei Zhou; Yun Li; Ling Lu; Yunzhang Liu; Jianfeng Zhou; Cunming Duan
Journal: PLoS One Date: 2014-06-11 Impact factor: 3.240