| Literature DB >> 22688484 |
Ashraf Said1, Ashraf Elbahrawy, Mohamed Alfiomy, Mohamed Abdellah, Khaled Shahat, Mohamed Salah, Sadek Mostafa, Ahmed Elwassief, Attef Aboelfotoh, Hafez Abdelhafeez, Assem El-Sherif.
Abstract
A 55-year-old Egyptian woman with chronic hepatitis C undergoing treatment with pegylated interferon (Peg-IFN) alfa-2a plus ribavirin was referred to our hospital on November 2010 with prolonged easy fatigability and an attack of syncope; she had no prior history of autoimmune disorders or allergy. Laboratory investigations documented the presence of Peg-IFN induced autoimmune haemolytic anaemia and autoimmune thyroiditis. Intravenous γ globulin (IVGG) failed to correct the autoimmune process; on the other hand steroid therapy dramatically corrected both haematological and thyroid values, and step down the immune process. Our report indicated that Peg-IFN de novo-induce autoimmune haemolysis, documenting a previous report. IVGG failed to step down the immune process in our case.Entities:
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Year: 2011 PMID： 22688484 PMCID： PMC3158342 DOI： 10.1136/bcr.06.2011.4400
Source DB: PubMed Journal: BMJ Case Rep ISSN： 1757-790X