| Literature DB >> 22688425 |
Latt Latt Aung1, Andrew Brooks, Steven A Greenberg, Michael L Rosenberg, Suhayl Dhib-Jalbut, Konstantin E Balashov.
Abstract
The cause of multiple sclerosis (MS) is not known and the mechanism of interferon-beta, a disease-modifying treatment, is not well-understood. We studied gene expression in plasmacytoid dendritic cells (pDCs), antigen-presenting cells implicated in MS pathogenesis. PDCs were separated from healthy donors and MS patients at two time points: before and after initiation of treatment with interferon-beta. Expression of selected MS-linked and interferon-beta-regulated genes was validated with single assays. We have identified 60 genes which were abnormally expressed in MS patients and were corrected after treatment. These genes could be studied as potential MS biomarkers and possible therapeutic targets in MS.Entities:
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Year: 2012 PMID： 22688425 PMCID： PMC3418446 DOI： 10.1016/j.jneuroim.2012.05.013
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478