Ultrastructure of human gametes, fertilization and embryos in assisted reproduction: a personal survey.

This extensively illustrated review will cover the progression of recent research on the ultrastructure of human gametes, fertilization and embryos performed in collaboration with colleagues in In vitro fertilization (IVF) centers over the past three decades, in Australia, Singapore, India, England, Sri Lanka, Spain and Italy. It will also include some aspects of gametogenesis and embryogenesis, particularly in relation to the centrosome that activates embryonic development, and is inherited from the father at fertilization. Assessment of both normal and abnormal gametes and embryos and some clinical aspects of assisted reproduction will be discussed. Full reference will also be made to the contribution of other groups to the ultrastructure of reproduction, particularly in humans.