Integrated simulation with experimentation is a powerful tool for understanding diatom valve morphogenesis.

We present a number of promising examples of computational studies, which improve our understanding of the morphogenesis process of diatom cell walls. Each example considers a different physical scenario whereby computational and mathematical models are used to evaluate hypotheses pertaining to diatom valve formation; considering the roles of cytoskeletal elements, interactions between cell components that might generate patterned structures from the submicron (nanoscale) to cell level, and the effect of environmental variables. We propose that the complex, multiscale phenomenon of diatom valve morphogenesis requires better integration of computational/mathematical and experimental procedures if we are to untangle all the contributing processes. Finally we outline a plan for future directions, to achieve this integration and further the field of diatom morphogenesis research.