Literature DB >> 2268678

Neutral surface aminopeptidase activity of human tumor cell lines.

A A Amoscato1, R M Sramkoski, G F Babcock, J W Alexander.   

Abstract

Seven human tumor cell lines were studied for their neutral surface aminopeptidase (AP) activity. The activity was shown to exist on all cell lines to varying degrees. The neutral AP activity of the cell lines had similar Km values and were affected by the same inhibitors as those reported for AP's of peripheral blood lymphocytes (PBL, Refs. 1 and 2). However, a difference was seen in the Vmax values of the various cell lines. These values were shown to correlate (r = 0.767, P less than 0.05) with cell surface area.

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Year:  1990        PMID： 2268678     DOI： 10.1016/0167-4838(90)90291-m

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis.

Authors:  Li Su; Jiangying Cao; Yuping Jia; Xiaonan Zhang; Hao Fang; Wenfang Xu
Journal:  ACS Med Chem Lett       Date:  2012-09-21       Impact factor: 4.345

2.  Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13.

Authors:  H Fujii; M Nakajima; I Saiki; J Yoneda; I Azuma; T Tsuruo
Journal:  Clin Exp Metastasis       Date:  1995-09       Impact factor: 5.150

3.  CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis.

Authors:  Eleonora Dondossola; Roberto Rangel; Liliana Guzman-Rojas; Elena M Barbu; Hitomi Hosoya; Lisa S St John; Jeffrey J Molldrem; Angelo Corti; Richard L Sidman; Wadih Arap; Renata Pasqualini
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-02       Impact factor: 11.205

4.  Inhibition of tumor invasion and extracellular matrix degradation by ubenimex (bestatin).

Authors:  J Yoneda; I Saiki; H Fujii; F Abe; Y Kojima; I Azuma
Journal:  Clin Exp Metastasis       Date:  1992-01       Impact factor: 5.150

5.  The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13).

Authors:  H Murray; A J Turner; A J Kenny
Journal:  Biochem J       Date:  1994-03-01       Impact factor: 3.857

6.  In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy.

Authors:  Layla Al-Mansoori; Sara S Bashraheel; Alanod D Al Qahtani; C David O'Connor; Philip Elsinga; Sayed K Goda
Journal:  Oncotarget       Date:  2020-02-11

7.  The main neutral aminopeptidase activity of human lymphoid tumour cell lines does not originate from the aminopeptidase N-(APN; CD13) gene.

Authors:  T Wex; U Lendeckel; T Kähne; A Ittenson; K Frank; S Ansorge
Journal:  Biochim Biophys Acta       Date:  1997-02-04

8.  Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity.

Authors:  K Ino; S Goto; T Okamoto; S Nomura; A Nawa; K Isobe; S Mizutani; Y Tomoda
Journal:  Jpn J Cancer Res       Date:  1994-09

9.  Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation.

Authors:  I Saiki; H Fujii; J Yoneda; F Abe; M Nakajima; T Tsuruo; I Azuma
Journal:  Int J Cancer       Date:  1993-04-22       Impact factor: 7.396
  9 in total

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