Literature DB >> 22686471

One-pot synthesis of phthalazines and pyridazino-aromatics: a novel strategy for substituted naphthalenes.

Simon N Kessler1, Hermann A Wegner.   

Abstract

A new one-pot strategy for the synthesis of phthalazines and pyridazino-aromatics starting from aromatic aldehydes has been developed. A variety of substituents ranging from electron withdrawing to donating is tolerated furnishing the desired 1,2-diazine in good to excellent yields. The products have been applied to the bidentate Lewis acid catalyzed inverse electron-demand Diels-Alder (IEDDA) reaction opening a novel two-step entry into substituted naphthalenes, such as Naproxen.

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Year:  2012        PMID： 22686471     DOI： 10.1021/ol301167q

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Non-precious metals catalyze formal [4 + 2] cycloaddition reactions of 1,2-diazines and siloxyalkynes under ambient conditions.

Authors:  Chintan S Sumaria; Yunus E Türkmen; Viresh H Rawal
Journal:  Org Lett       Date:  2014-06-09       Impact factor: 6.005

2.  Multi Component Reactions under Increased Pressure: On the Mechanism of Formation of Pyridazino[5,4,3-de][1,6]naphthyridine Derivatives by the Reaction of Malononitrile, Aldehydes and 2-Oxoglyoxalarylhydrazones in Q-Tubes.

Authors:  Majdah A Al-Johani; Khadijah M Al-Zaydi; Sameera M Mousally; Norah F Alqahtani; Noha Hilmy Elnagdi; Mohamed H Elnagdi
Journal:  Molecules       Date:  2017-12-01       Impact factor: 4.411
  2 in total

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