Literature DB >> 22684584

At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone.

John Foley1, Nicole Nickerson, David J Riese, Peter C Hollenhorst, Gwendolen Lorch, Anne M Foley.   

Abstract

The epidermal growth factor receptor is a well-established cancer therapeutic target due to its stimulation of proliferation, motility, and resistance to apoptosis. Recently, additional roles for the receptor have been identified in growth of metastases. Similar to development, metastatic spread requires signaling interactions between epithelial-derived tumor cells and mesenchymal derivatives of the microenvironment. This necessitates reactivation of developmental signaling molecules, including the hypercalcemia factor parathyroid hormone-related protein. This review covers the variations of epidermal growth factor receptor signaling in cancers that produce bone metastases, regulation of parathyroid hormone-related protein, and evidence that the two molecules drive cancer-mediated diseases of bone.

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Year:  2012        PMID： 22684584      PMCID： PMC3962551          DOI： 10.1007/s10266-012-0070-5

Source DB:  PubMed          Journal:  Odontology        ISSN： 1618-1247            Impact factor:   2.634


  200 in total

1.  Ligand discrimination in signaling through an ErbB4 receptor homodimer.

Authors:  C Sweeney; C Lai; D J Riese; A J Diamonti; L C Cantley; K L Carraway
Journal:  J Biol Chem       Date:  2000-06-30       Impact factor: 5.157

2.  Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.

Authors:  Nathaniel D Heintzman; Rhona K Stuart; Gary Hon; Yutao Fu; Christina W Ching; R David Hawkins; Leah O Barrera; Sara Van Calcar; Chunxu Qu; Keith A Ching; Wei Wang; Zhiping Weng; Roland D Green; Gregory E Crawford; Bing Ren
Journal:  Nat Genet       Date:  2007-02-04       Impact factor: 38.330

3.  Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells.

Authors:  Peter C Hollenhorst; Mary W Ferris; Megan A Hull; Heejoon Chae; Sun Kim; Barbara J Graves
Journal:  Genes Dev       Date:  2011-10-15       Impact factor: 11.361

4.  Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway.

Authors:  Ling Qin; Nicola C Partridge
Journal:  J Cell Biochem       Date:  2005-10-15       Impact factor: 4.429

5.  Breast cancer cells interact with osteoblasts to support osteoclast formation.

Authors:  R J Thomas; T A Guise; J J Yin; J Elliott; N J Horwood; T J Martin; M T Gillespie
Journal:  Endocrinology       Date:  1999-10       Impact factor: 4.736

6.  Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein.

Authors:  R M Kris; I Lax; W Gullick; M D Waterfield; A Ullrich; M Fridkin; J Schlessinger
Journal:  Cell       Date:  1985-03       Impact factor: 41.582

7.  Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting.

Authors:  John C Sok; Francesca M Coppelli; Sufi M Thomas; Miriam N Lango; Sichuan Xi; Jennifer L Hunt; Maria L Freilino; Michael W Graner; Carol J Wikstrand; Darell D Bigner; William E Gooding; Frank B Furnari; Jennifer R Grandis
Journal:  Clin Cancer Res       Date:  2006-09-01       Impact factor: 12.531

8.  Lung cancer incidence in never smokers.

Authors:  Heather A Wakelee; Ellen T Chang; Scarlett L Gomez; Theresa H Keegan; Diane Feskanich; Christina A Clarke; Lars Holmberg; Lee C Yong; Laurence N Kolonel; Michael K Gould; Dee W West
Journal:  J Clin Oncol       Date:  2007-02-10       Impact factor: 44.544

9.  HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms.

Authors:  Bart S Hendriks; H Steven Wiley; Douglas Lauffenburger
Journal:  Biophys J       Date:  2003-10       Impact factor: 4.033

10.  Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors.

Authors:  H Daub; F U Weiss; C Wallasch; A Ullrich
Journal:  Nature       Date:  1996-02-08       Impact factor: 49.962
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  8 in total

1.  Extracellular signal-regulated kinase signaling regulates the opposing roles of JUN family transcription factors at ETS/AP-1 sites and in cell migration.

Authors:  Nagarathinam Selvaraj; Justin A Budka; Mary W Ferris; Joshua P Plotnik; Peter C Hollenhorst
Journal:  Mol Cell Biol       Date:  2014-10-20       Impact factor: 4.272

Review 2.  The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma.

Authors:  Shumin Xie; Xiaoli Wang; Jihao Ren; Wei Liu
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-12-16       Impact factor: 2.503

Review 3.  Reversion of the ErbB malignant phenotype and the DNA damage response.

Authors:  E Aaron Runkle; Hongtao Zhang; Zheng Cai; Zhiqiang Zhu; Barry L Karger; Shiaw-Lin Wu; Donald M O'Rourke; Zhaocai Zhou; Qiang Wang; Mark I Greene
Journal:  Exp Mol Pathol       Date:  2012-09-27       Impact factor: 3.362

Review 4.  Multiple Myeloma and Bone: The Fatal Interaction.

Authors:  Silvia Marino; G David Roodman
Journal:  Cold Spring Harb Perspect Med       Date:  2018-08-01       Impact factor: 6.915

Review 5.  Animal Models of Bone Metastasis.

Authors:  J K Simmons; B E Hildreth; W Supsavhad; S M Elshafae; B B Hassan; W P Dirksen; R E Toribio; T J Rosol
Journal:  Vet Pathol       Date:  2015-05-28       Impact factor: 2.221

6.  Tumor microenvironment regulates metastasis and metastasis genes of mouse MMTV-PymT mammary cancer cells in vivo.

Authors:  J L Werbeck; N K Thudi; C K Martin; C Premanandan; L Yu; M C Ostrowksi; T J Rosol
Journal:  Vet Pathol       Date:  2013-10-03       Impact factor: 2.221

7.  Inhibition of epidermal growth factor receptor suppresses parathyroid hormone-related protein expression in tumours and ameliorates cancer-associated cachexia.

Authors:  Bahar Zehra Camurdanoglu Weber; Samet Agca; Aylin Domaniku; Sevval Nur Bilgic; Dilsad H Arabaci; Serkan Kir
Journal:  J Cachexia Sarcopenia Muscle       Date:  2022-04-04       Impact factor: 12.063

Review 8.  Fibroblasts as Modulators of Local and Systemic Cancer Metabolism.

Authors:  Hannah Sanford-Crane; Jaime Abrego; Mara H Sherman
Journal:  Cancers (Basel)       Date:  2019-05-03       Impact factor: 6.639
  8 in total

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