Literature DB >> 22684456

Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells.

Matthew Wortham1, Hai Yan.   

Abstract

The mechanisms whereby medulloblastoma stem cells coordinate tumor propagation are poorly understood. Using microarray analysis, Corno and colleagues draw parallels and distinctions between medulloblastoma stem cells from the Ptch(+/-) mouse and normal neural stem cells, identifying Ebf3 as a cancer stem cell-specific transcript critical for tumor growth.

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Year:  2012        PMID： 22684456      PMCID： PMC3375910          DOI： 10.1158/2159-8290.CD-12-0182

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  10 in total

1.  Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human medulloblastoma molecular classification.

Authors:  Daniela Corno; Corno Daniela; Mauro Pala; Manuela Cominelli; Barbara Cipelletti; Ketty Leto; Laura Croci; Valeria Barili; Federico Brandalise; Raffaella Melzi; Alessandra Di Gregorio; Lucia Sergi Sergi; Letterio Salvatore Politi; Lorenzo Piemonti; Alessandro Bulfone; Paola Rossi; Ferdinando Rossi; Gian Giacomo Consalez; Pietro Luigi Poliani; Rossella Galli
Journal:  Cancer Discov       Date:  2012-05-03       Impact factor: 39.397

2.  An animal model of MYC-driven medulloblastoma.

Authors:  Yanxin Pei; Colin E Moore; Jun Wang; Alok K Tewari; Alexey Eroshkin; Yoon-Jae Cho; Hendrik Witt; Andrey Korshunov; Tracy-Ann Read; Julia L Sun; Earlene M Schmitt; C Ryan Miller; Anne F Buckley; Roger E McLendon; Thomas F Westbrook; Paul A Northcott; Michael D Taylor; Stefan M Pfister; Phillip G Febbo; Robert J Wechsler-Reya
Journal:  Cancer Cell       Date:  2012-02-14       Impact factor: 31.743

3.  Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

Authors:  Trudy G Oliver; Tracy Ann Read; Jessica D Kessler; Anriada Mehmeti; Jonathan F Wells; Trang T T Huynh; Simon M Lin; Robert J Wechsler-Reya
Journal:  Development       Date:  2005-04-20       Impact factor: 6.868

4.  Medulloblastoma comprises four distinct molecular variants.

Authors:  Paul A Northcott; Andrey Korshunov; Hendrik Witt; Thomas Hielscher; Charles G Eberhart; Stephen Mack; Eric Bouffet; Steven C Clifford; Cynthia E Hawkins; Pim French; James T Rutka; Stefan Pfister; Michael D Taylor
Journal:  J Clin Oncol       Date:  2010-09-07       Impact factor: 44.544

5.  PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.

Authors:  Dolores Hambardzumyan; Oren J Becher; Marc K Rosenblum; Pier Paolo Pandolfi; Katia Manova-Todorova; Eric C Holland
Journal:  Genes Dev       Date:  2008-02-15       Impact factor: 11.361

6.  Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.

Authors:  Tracy-Ann Read; Marie P Fogarty; Shirley L Markant; Roger E McLendon; Zhengzheng Wei; David W Ellison; Phillip G Febbo; Robert J Wechsler-Reya
Journal:  Cancer Cell       Date:  2009-02-03       Impact factor: 31.743

7.  Cross-species genomics matches driver mutations and cell compartments to model ependymoma.

Authors:  Robert A Johnson; Karen D Wright; Helen Poppleton; Kumarasamypet M Mohankumar; David Finkelstein; Stanley B Pounds; Vikki Rand; Sarah E S Leary; Elsie White; Christopher Eden; Twala Hogg; Paul Northcott; Stephen Mack; Geoffrey Neale; Yong-Dong Wang; Beth Coyle; Jennifer Atkinson; Mariko DeWire; Tanya A Kranenburg; Yancey Gillespie; Jeffrey C Allen; Thomas Merchant; Fredrick A Boop; Robert A Sanford; Amar Gajjar; David W Ellison; Michael D Taylor; Richard G Grundy; Richard J Gilbertson
Journal:  Nature       Date:  2010-07-18       Impact factor: 49.962

8.  Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma.

Authors:  Ryan J Ward; Lilian Lee; Kevin Graham; Thevagi Satkunendran; Koichi Yoshikawa; Erick Ling; Lauren Harper; Ryan Austin; Erica Nieuwenhuis; Ian D Clarke; Chi-Chung Hui; Peter B Dirks
Journal:  Cancer Res       Date:  2009-06-01       Impact factor: 12.701

9.  Subtypes of medulloblastoma have distinct developmental origins.

Authors:  Paul Gibson; Yiai Tong; Giles Robinson; Margaret C Thompson; D Spencer Currle; Christopher Eden; Tanya A Kranenburg; Twala Hogg; Helen Poppleton; Julie Martin; David Finkelstein; Stanley Pounds; Aaron Weiss; Zoltan Patay; Matthew Scoggins; Robert Ogg; Yanxin Pei; Zeng-Jie Yang; Sonja Brun; Youngsoo Lee; Frederique Zindy; Janet C Lindsey; Makoto M Taketo; Frederick A Boop; Robert A Sanford; Amar Gajjar; Steven C Clifford; Martine F Roussel; Peter J McKinnon; David H Gutmann; David W Ellison; Robert Wechsler-Reya; Richard J Gilbertson
Journal:  Nature       Date:  2010-12-08       Impact factor: 49.962

10.  Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.

Authors:  Ulrich Schüller; Vivi M Heine; Junhao Mao; Alvin T Kho; Allison K Dillon; Young-Goo Han; Emmanuelle Huillard; Tao Sun; Azra H Ligon; Ying Qian; Qiufu Ma; Arturo Alvarez-Buylla; Andrew P McMahon; David H Rowitch; Keith L Ligon
Journal:  Cancer Cell       Date:  2008-08-12       Impact factor: 31.743
  10 in total
  1 in total

1.  Similarity on neural stem cells and brain tumor stem cells in transgenic brain tumor mouse models.

Authors:  Guanqun Qiao; Qingquan Li; Gang Peng; Jun Ma; Hongwei Fan; Yingbin Li
Journal:  Neural Regen Res       Date:  2013-09-05       Impact factor: 5.135
  1 in total

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