Literature DB >> 22684082

Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format.

Kathrin Zuberbühler1, Giulio Casi, Gonçalo J L Bernardes, Dario Neri.   

Abstract

We describe a method that enables specific and efficient conjugation of hydrazide-moieties to an IgG targeting the tumor neovasculature. The resulting chemically defined, homogeneous hydrazone-linked IgG conjugates remain immunoreactive and have a half-life of approximately 18 hours at physiological pH and temperature suitable for localized delivery of toxic drugs.

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Year:  2012        PMID： 22684082     DOI： 10.1039/c2cc32412a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  18 in total

1.  Synthesis and structure-activity relationship studies of IgG-binding peptides focused on the C-terminal histidine residue.

Authors:  Kyohei Muguruma; Mayu Ito; Akane Fukuda; Satoshi Kishimoto; Akihiro Taguchi; Kentaro Takayama; Atsuhiko Taniguchi; Yuji Ito; Yoshio Hayashi
Journal:  Medchemcomm       Date:  2019-08-01       Impact factor: 3.597

2.  Site-specific chemical modification of antibody fragments using traceless cleavable linkers.

Authors:  Gonçalo J L Bernardes; Martina Steiner; Isabelle Hartmann; Dario Neri; Giulio Casi
Journal:  Nat Protoc       Date:  2013-10-03       Impact factor: 13.491

Review 3.  Strategies and challenges for the next generation of antibody-drug conjugates.

Authors:  Alain Beck; Liliane Goetsch; Charles Dumontet; Nathalie Corvaïa
Journal:  Nat Rev Drug Discov       Date:  2017-03-17       Impact factor: 84.694

4.  Preparation of well-defined antibody-drug conjugates through glycan remodeling and strain-promoted azide-alkyne cycloadditions.

Authors:  Xiuru Li; Tao Fang; Geert-Jan Boons
Journal:  Angew Chem Int Ed Engl       Date:  2014-05-23       Impact factor: 15.336

5.  Click Chemistry Conjugations.

Authors:  Tak Ian Chio; Susan L Bane
Journal:  Methods Mol Biol       Date:  2020

Review 6.  Review transglutaminases: part II-industrial applications in food, biotechnology, textiles and leather products.

Authors:  Lovaine Duarte; Carla Roberta Matte; Cristiano Valim Bizarro; Marco Antônio Záchia Ayub
Journal:  World J Microbiol Biotechnol       Date:  2019-12-26       Impact factor: 3.312

Review 7.  Glycoengineering of Antibodies for Modulating Functions.

Authors:  Lai-Xi Wang; Xin Tong; Chao Li; John P Giddens; Tiezheng Li
Journal:  Annu Rev Biochem       Date:  2019-03-27       Impact factor: 23.643

Review 8.  Field Guide to Challenges and Opportunities in Antibody-Drug Conjugates for Chemists.

Authors:  Mallory R Gordon; Mine Canakci; Longyu Li; Jiaming Zhuang; Barbara Osborne; S Thayumanavan
Journal:  Bioconjug Chem       Date:  2015-09-10       Impact factor: 4.774

Review 9.  The Chemistry Behind ADCs.

Authors:  Vesela Kostova; Patrice Désos; Jérôme-Benoît Starck; Andras Kotschy
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-07

Review 10.  Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development.

Authors:  Paresh Agarwal; Carolyn R Bertozzi
Journal:  Bioconjug Chem       Date:  2015-01-30       Impact factor: 4.774
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