Yun-Hao Tang1, Tian-Fu Wen, Xi Chen. 1. Department of Liver and Vascular Surgery, Sichuan University, Chengdu, Sichuan Province, China.
Abstract
BACKGROUND/AIMS: To evaluate the influence of the width of resection margin on recurrence and survival for hepatocellular carcinoma. METHODOLOGY: Randomized controlled trials and non-randomized trials evaluating the influence of the width of resection margin for HCC were identified using a predefined search strategy. A meta-analysis was performed to estimate pooled recurrence and survival rate. RESULTS: One randomized controlled trial and four non-randomized trials were identified. The only randomized controlled trial reported that a margin aiming at 2cm could decrease the recurrence rate (p=0.037) and increase the 3-year survival (p=0.02) and 5-year survival rate (p<0.01) compared with a margin aiming at 1cm. Meta-analysis showed that there was no significant difference between the group with resection margin <1cm and the group with resection margin ≥1cm in recurrence rate (p=0.08), 1-year survival (p=0.75), 3-year survival (p=0.53) and 5-year survival rate (p=0.15). CONCLUSIONS: A resection margin ≥1cm does not provide significant prognostic benefit compared with a resection margin <1cm. There is limited evidence to show that patients with a resection margin aiming at 2cm have better survival outcome than patients with a resection margin aiming at 1cm.
BACKGROUND/AIMS: To evaluate the influence of the width of resection margin on recurrence and survival for hepatocellular carcinoma. METHODOLOGY: Randomized controlled trials and non-randomized trials evaluating the influence of the width of resection margin for HCC were identified using a predefined search strategy. A meta-analysis was performed to estimate pooled recurrence and survival rate. RESULTS: One randomized controlled trial and four non-randomized trials were identified. The only randomized controlled trial reported that a margin aiming at 2cm could decrease the recurrence rate (p=0.037) and increase the 3-year survival (p=0.02) and 5-year survival rate (p<0.01) compared with a margin aiming at 1cm. Meta-analysis showed that there was no significant difference between the group with resection margin <1cm and the group with resection margin ≥1cm in recurrence rate (p=0.08), 1-year survival (p=0.75), 3-year survival (p=0.53) and 5-year survival rate (p=0.15). CONCLUSIONS: A resection margin ≥1cm does not provide significant prognostic benefit compared with a resection margin <1cm. There is limited evidence to show that patients with a resection margin aiming at 2cm have better survival outcome than patients with a resection margin aiming at 1cm.
Authors: Matthew M Yeh; Raymond S Yeung; Smith Apisarnthanarax; Renuka Bhattacharya; Carlos Cuevas; William P Harris; Tony Lim Kiat Hon; Siddharth A Padia; James O Park; Kevin M Riggle; Sayed S Daoud Journal: World J Hepatol Date: 2015-06-18
Authors: Tiffany Cho Lam Wong; Tan To Cheung; Kenneth S H Chok; Albert C Y Chan; Wing Chiu Dai; See Ching Chan; Ronnie T P Poon; Chung Mau Lo Journal: World J Surg Date: 2014-09 Impact factor: 3.352