Literature DB >> 2268329

Molecular cloning and characterization of cDNA for the precursor of rat pituitary adenylate cyclase activating polypeptide (PACAP).

K Ogi1, C Kimura, H Onda, A Arimura, M Fujino.   

Abstract

We have isolated and cloned a cDNA for rat pituitary adenylate cyclase activating polypeptide (PACAP) precursor protein from the brain. The nucleotide and the deduced amino acid sequences revealed that the rat PACAP cDNA encoded a 175 amino acid protein highly homologous to the ovine and human PACAP precursors. The rat PACAP precursor protein included a putative signal peptide at the amino-terminus, a PACAP-related peptide (PRP) of 29 amino acid residues and the rat PACAP of 38 amino acid residues flanked by basic processing sites, and a carboxy-teminus amidation signal for PACAP. Furthermore, the amino acid sequence of the rat PACAP was completely identical to that of the ovine and human PACAP. Northern blot analysis of rat brain RNA revealed an approximately 3.0 kb transcript for the PACAP precursor in rat brain.

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Year:  1990        PMID： 2268329     DOI： 10.1016/s0006-291x(05)80924-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  28 in total

1.  New nucleotide sequence data on the EMBL File Server.

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2.  Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.

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Journal:  Hum Mol Genet       Date:  2005-05-11       Impact factor: 6.150

3.  The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.

Authors:  Chee Yeun Chung; Pawel Licznerski; Kambiz N Alavian; Antonio Simeone; Zhicheng Lin; Eden Martin; Jeffery Vance; Ole Isacson
Journal:  Brain       Date:  2010-06-23       Impact factor: 13.501

4.  Pituitary adenylate cyclase-activating peptide-immunoreactive nerve fibers in the cat eye.

Authors:  T Elsås; R Uddman; F Sundler
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-09       Impact factor: 3.117

5.  Distribution of pituitary adenylyl cyclase activating peptide (PACAP) immunoreactivity in neurons of the guinea-pig digestive tract and their projections in the ileum and colon.

Authors:  A L Portbury; K McConalogue; J B Furness; H M Young
Journal:  Cell Tissue Res       Date:  1995-02       Impact factor: 5.249

Review 6.  Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons: functional implications from plasticity in expression on nerve injury and inflammation.

Authors:  H Mulder; H Jongsma; Y Zhang; S Gebre-Medhin; F Sundler; N Danielsen
Journal:  Mol Neurobiol       Date:  1999-06       Impact factor: 5.590

7.  Pituitary adenylate cyclase-activating polypeptide expression and modulation of neuronal excitability in guinea pig cardiac ganglia.

Authors:  K M Braas; V May; S A Harakall; J C Hardwick; R L Parsons
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

8.  Distribution and molecular evolution of the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the lizard Podarcis sicula (Squamata, Lacertidae).

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Journal:  J Mol Neurosci       Date:  2009-01-28       Impact factor: 3.444

Review 9.  Neuropeptides of the pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide/growth hormone-releasing hormone/secretin family in testis.

Authors:  Min Li; Akira Arimura
Journal:  Endocrine       Date:  2003-04       Impact factor: 3.633

10.  Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor.

Authors:  J R Pisegna; S A Wank
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205
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