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Literature DB >> 2268299

Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body.

A R Cross¹, L Henderson, O T Jones, M A Delpiano, J Hentschel, H Acker.

Abstract

The rat carotid body tissue reveals a photometrically measurable haem signal with absorbance maxima at 560 nm, 518 nm and 425 nm, suggesting the presence of a b-type cytochrome; this was confirmed by pyridine haemochrome and CO spectra. The quantity of cytochrome b was estimated to be 310 pmol.mg of protein-1. This haem is capable of H2O2 formation, which can be inhibited by 10 microM-diphenyliodonium (DPI). The hypoxia-induced increase in nervous chemoreceptor discharge and the reduction of FAD and NAD(P)+ were also inhibited by DPI (10 microM). These results suggest that an oxidase such as the NAD(P)H oxidase of neutrophils may act as a pO2 sensor protein in the rat carotid body, probably inducing the pO2 chemoreceptor process by H2O2 formation.

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Year: 1990 PMID： 2268299 PMCID： PMC1149771 DOI： 10.1042/bj2720743

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

25 in total

1. Studies on ferrochelatase. 2. An in vestigation of the role offerrochelatase in the biosynthesis of various haem prosthetic groups.

Authors: R J PORRA; O T JONES
Journal: Biochem J Date: 1963-04 Impact factor: 3.857

2. Soluble guanylate cyclase purified from bovine lung contains heme and copper.

Authors: R Gerzer; E Böhme; F Hofmann; G Schultz
Journal: FEBS Lett Date: 1981-09-14 Impact factor: 4.124

3. Decrease in apparent Km for oxygen after stimulation of respiration of rat polymorphonuclear leukocytes.

Authors: S W Edwards; M B Hallett; D Lloyd; A K Campbell
Journal: FEBS Lett Date: 1983-09-05 Impact factor: 4.124

4. The enzymic reduction and kinetics of oxidation of cytochrome b-245 of neutrophils.

Authors: A R Cross; F K Higson; O T Jones; A M Harper; A W Segal
Journal: Biochem J Date: 1982-05-15 Impact factor: 3.857

5. Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst.

Authors: A R Cross; O T Jones; A M Harper; A W Segal
Journal: Biochem J Date: 1981-02-15 Impact factor: 3.857

6. The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme.

Authors: T G Gabig; B M Babior
Journal: J Biol Chem Date: 1979-09-25 Impact factor: 5.157

7. Apparent Km of leukocyte O2 and H2O2 forming enzyme for oxygen.

Authors: K Kakinuma; M Kaneda
Journal: Adv Exp Med Biol Date: 1982 Impact factor: 2.622

8. The effects of diphenyleneiodonium on mitochondrial reactions. Relation of binding of diphenylene[125I]iodonium to mitochondria to the extent of inhibition of oxygen uptake.

Authors: S J Gatley; S A Sherratt
Journal: Biochem J Date: 1976-08-15 Impact factor: 3.857

9. Role of arterial O2 flow in peripheral chemoreceptor excitation.

Authors: S Lahiri
Journal: Fed Proc Date: 1980-07

10. The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations.

Authors: A R Cross; J F Parkinson; O T Jones
Journal: Biochem J Date: 1984-10-15 Impact factor: 3.857

41 in total

Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body.

1. Studies on ferrochelatase. 2. An in vestigation of the role offerrochelatase in the biosynthesis of various haem prosthetic groups.

2. Soluble guanylate cyclase purified from bovine lung contains heme and copper.

3. Decrease in apparent Km for oxygen after stimulation of respiration of rat polymorphonuclear leukocytes.

4. The enzymic reduction and kinetics of oxidation of cytochrome b-245 of neutrophils.

5. Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst.

6. The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme.

7. Apparent Km of leukocyte O2 and H2O2 forming enzyme for oxygen.

8. The effects of diphenyleneiodonium on mitochondrial reactions. Relation of binding of diphenylene[125I]iodonium to mitochondria to the extent of inhibition of oxygen uptake.

9. Role of arterial O2 flow in peripheral chemoreceptor excitation.

10. The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations.

1. Oxygen sensing and K(+)-Cl(-) cotransport.

Review 2. Reactive oxygen intermediates involved in cellular regulation.

Review 3. The oxygen sensing signal cascade under the influence of reactive oxygen species.

Review 4. The role of NADPH oxidase in carotid body arterial chemoreceptors.

Review 5. Transduction of chemostimuli by the type I carotid body cell.

6. Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells.

7. O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase.

8. Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells.

9. Rac1, and not Rac2, is involved in the regulation of the intracellular hydrogen peroxide level in HepG2 cells.

10. Selective modulation of membrane currents by hypoxia in intact airway chemoreceptors from neonatal rabbit.