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Literature DB >> 2268281

Hepatic iodothyronine 5'-deiodinase. The role of selenium.

Abstract

Selenium (Se) deficiency decreased by 8-fold the activity of type 1 iodothyronine 5'-deiodinase (ID-I) in hepatic microsomal fractions from rats. Solubilized hepatic microsomes from rats injected with 75Se-labelled Na2SeO3 4 days before killing were found by chromatography on agarose gels to contain a 75Se-containing fraction with ID-I activity. PAGE of this fraction under reducing conditions, followed by autoradiography, revealed a single 75Se-containing protein (Mr 27,400 +/- 300). This protein could also be labelled with 125I-bromoacetyl reverse tri-iodothyronine, an affinity label for ID-I. The results suggest that hepatic ID-I is a selenoprotein or has an Se-containing subunit essential for activity.

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Year: 1990 PMID： 2268281 PMCID： PMC1149735 DOI： 10.1042/bj2720537

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

14 in total

1. Subcellular distribution of selenoproteins in the liver of the rat.

Authors: D Behne; S Scheid; A Kyriakopoulos; H Hilmert
Journal: Biochim Biophys Acta Date: 1990-03-26

2. Inhibition of type I and type II iodothyronine deiodinase activity in rat liver, kidney and brain produced by selenium deficiency.

Authors: G J Beckett; D A MacDougall; F Nicol; R Arthur
Journal: Biochem J Date: 1989-05-01 Impact factor: 3.857

3. Partial purification of the microsomal rat liver iodothyronine deiodinase. I. Solubilization and ion-exchange chromatography.

Authors: J A Mol; T P van den Berg; T J Visser
Journal: Mol Cell Endocrinol Date: 1988-02 Impact factor: 4.102

4. Phospholipid hydroperoxide glutathione peroxidase: specific activity in tissues of rats of different age and comparison with other glutathione peroxidases.

Authors: L P Zhang; M Maiorino; A Roveri; F Ursini
Journal: Biochim Biophys Acta Date: 1989-11-06

5. The changes in hepatic enzyme expression caused by selenium deficiency and hypothyroidism in rats are produced by independent mechanisms.

Authors: G J Beckett; F Nicol; D Proudfoot; K Dyson; G Loucaides; J R Arthur
Journal: Biochem J Date: 1990-03-15 Impact factor: 3.857

6. Inhibition of hepatic deiodination of thyroxine is caused by selenium deficiency in rats.

Authors: G J Beckett; S E Beddows; P C Morrice; F Nicol; J R Arthur
Journal: Biochem J Date: 1987-12-01 Impact factor: 3.857

7. The effects of selenium and copper deficiencies on glutathione S-transferase and glutathione peroxidase in rat liver.

Authors: J R Arthur; P C Morrice; F Nicol; S E Beddows; R Boyd; J D Hayes; G J Beckett
Journal: Biochem J Date: 1987-12-01 Impact factor: 3.857

8. Properties of cytosolic components activating rat hepatic 5' [corrected]-deiodination in the presence of NADPH.

Authors: K Sawada; B C Hummel; P G Walfish
Journal: Biochem J Date: 1986-03-01 Impact factor: 3.857

9. Evidence for specific selenium target tissues and new biologically important selenoproteins.

Authors: D Behne; H Hilmert; S Scheid; H Gessner; W Elger
Journal: Biochim Biophys Acta Date: 1988-07-14

10. Affinity labeling of rat liver thyroid hormone nuclear receptor.

Authors: V M Nikodem; S Y Cheng; J E Rall
Journal: Proc Natl Acad Sci U S A Date: 1980-12 Impact factor: 11.205

34 in total

1. Micronutrient deficiencies: public health implications.

Authors: C Gopalan
Journal: Indian J Pediatr Date: 1995 Mar-Apr Impact factor: 1.967

Review 2. The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism.

Authors: J R Arthur; F Nicol; G J Beckett
Journal: Biol Trace Elem Res Date: 1992 Apr-Jun Impact factor: 3.738

Review 3. Selenium metabolism and bioavailability.

Authors: L A Daniels
Journal: Biol Trace Elem Res Date: 1996-09 Impact factor: 3.738

4. Selenoprotein gene expression during selenium-repletion of selenium-deficient rats.

Authors: G Bermano; F Nicol; J A Dyer; R A Sunde; G J Beckett; J R Arthur; J E Hesketh
Journal: Biol Trace Elem Res Date: 1996-03 Impact factor: 3.738

Review 5. Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction.

Authors: R I Henkin
Journal: Drug Saf Date: 1994-11 Impact factor: 5.606

6. Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme.

Authors: D Salvatore; S C Low; M Berry; A L Maia; J W Harney; W Croteau; D L St Germain; P R Larsen
Journal: J Clin Invest Date: 1995-11 Impact factor: 14.808

7. Differential selenium-dependent expression of type I 5'-deiodinase and glutathione peroxidase in the porcine epithelial kidney cell line LLC-PK1.

Authors: M Gross; M Oertel; J Köhrle
Journal: Biochem J Date: 1995-03-15 Impact factor: 3.857

8. Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer.

Authors: G Bermano; V Pagmantidis; N Holloway; S Kadri; N A G Mowat; R S Shiel; J R Arthur; J C Mathers; A K Daly; J Broom; J E Hesketh
Journal: Genes Nutr Date: 2007-10-13 Impact factor: 5.523

9. Effect of selenium deficiency on hepatic type I 5-iodothyronine deiodinase activity and hepatic thyroid hormone levels in the rat.

Authors: G J Beckett; A Russell; F Nicol; P Sahu; C R Wolf; J R Arthur
Journal: Biochem J Date: 1992-03-01 Impact factor: 3.857

10. Selenium status in infants and children with phenylketonuria and in maternal phenylketonuria.

Authors: I Lombeck; F Jochum; K Terwolbeck
Journal: Eur J Pediatr Date: 1996-07 Impact factor: 3.183