BACKGROUND AND PURPOSE: To assess and compare the incidence of intra- and extracranial tumours and mortality in pituitary adenoma patients treated with postoperative radiotherapy and surgery alone. PATIENTS AND METHODS: A total of 462 pituitary adenoma patients were treated between 1959 and 2008 at the University Medical Center Groningen in The Netherlands. Postoperative radiotherapy was administered on indication in 236 patients. RESULTS: The median follow-up time was 14 (range 1-49) years in patients treated with radiotherapy and 6 (range 1-34) years in patients treated with surgery alone. Three radiotherapy patients developed an intracranial tumour compared to one patient treated with surgery alone. The numbers of extracranial tumours per follow-up year were 6.5 (95% CI 2.5-10.5) and 5.1 (95% CI 1.9-8.2) in patients treated with and without a technique with vertex field and central body axis irradiation and 7.1 (CI 95% 2.9-11.2) in surgery alone patients. Forty-five patients treated with radiotherapy died compared to twenty-four patients treated with surgery alone (log-rank test RR 1.26, 95% CI 0.77-2.08, p=0.36). CONCLUSION: In this study postoperative radiotherapy and a radiotherapy treatment technique with vertex field and central body axis irradiation were not associated with an increased incidence of second tumours and mortality in pituitary adenoma patients.
BACKGROUND AND PURPOSE: To assess and compare the incidence of intra- and extracranial tumours and mortality in pituitary adenomapatients treated with postoperative radiotherapy and surgery alone. PATIENTS AND METHODS: A total of 462 pituitary adenomapatients were treated between 1959 and 2008 at the University Medical Center Groningen in The Netherlands. Postoperative radiotherapy was administered on indication in 236 patients. RESULTS: The median follow-up time was 14 (range 1-49) years in patients treated with radiotherapy and 6 (range 1-34) years in patients treated with surgery alone. Three radiotherapy patients developed an intracranial tumour compared to one patient treated with surgery alone. The numbers of extracranial tumours per follow-up year were 6.5 (95% CI 2.5-10.5) and 5.1 (95% CI 1.9-8.2) in patients treated with and without a technique with vertex field and central body axis irradiation and 7.1 (CI 95% 2.9-11.2) in surgery alone patients. Forty-five patients treated with radiotherapy died compared to twenty-four patients treated with surgery alone (log-rank test RR 1.26, 95% CI 0.77-2.08, p=0.36). CONCLUSION: In this study postoperative radiotherapy and a radiotherapy treatment technique with vertex field and central body axis irradiation were not associated with an increased incidence of second tumours and mortality in pituitary adenomapatients.
Authors: Paul D Brown; Miran Blanchard; Krishan Jethwa; Kelly D Flemming; Cerise A Brown; Robert W Kline; Debra J Jacobson; Jennifer St Sauver; Bruce E Pollock; Yolanda I Garces; Scott L Stafford; Michael J Link; Dana Erickson; Robert L Foote; Nadia N I Laack Journal: Neurooncol Pract Date: 2014-03
Authors: Beatriz Lecumberri; Javier Estrada; José García-Uría; Isabel Millán; Luis Felipe Pallardo; Luis Caballero; Tomás Lucas Journal: Pituitary Date: 2015-12 Impact factor: 4.107
Authors: G Cortês Nascimento; A G P de Araujo Cortês Nascimento; C de Maria Ribeiro Veiga Parente; V P Rodrigues; R S de Sousa Azulay; V C de Carvalho Rocha; S da Silva Pereira Damianse; M Magalhães; M Dos Santos Faria; M B Gomes Journal: J Endocrinol Invest Date: 2020-07-17 Impact factor: 4.256