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Literature DB >> 22682239

Dna2 offers support for stalled forks.

Abstract

The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing the reversal of stalled and terminal replication forks. Hu et al. now show that the ATR pathway targets the Dna2 nuclease to process stalled forks and counteract fork reversal.

Entities: Gene

Year: 2012 PMID： 22682239 DOI： 10.1016/j.cell.2012.05.021

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

8 in total

1. Replication forks reverse at high frequency upon replication stress in Physarum polycephalum.

Authors: Chrystelle Maric; Marianne Bénard
Journal: Chromosoma Date: 2014-06-21 Impact factor: 4.316

2. Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit.

Authors: Julie Meurisse; Agathe Bacquin; Nicolas Richet; Jean-Baptiste Charbonnier; Françoise Ochsenbein; Anne Peyroche
Journal: Nucleic Acids Res Date: 2014-11-06 Impact factor: 16.971

3. Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.

Authors: Gizem Ölmezer; Maryna Levikova; Dominique Klein; Benoît Falquet; Gabriele Alessandro Fontana; Petr Cejka; Ulrich Rass
Journal: Nat Commun Date: 2016-10-25 Impact factor: 14.919

4. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy.

Authors: Wenpeng Liu; Mian Zhou; Zhengke Li; Hongzhi Li; Piotr Polaczek; Huifang Dai; Qiong Wu; Changwei Liu; Kenneth K Karanja; Vencat Popuri; Shu-Ou Shan; Katharina Schlacher; Li Zheng; Judith L Campbell; Binghui Shen
Journal: EBioMedicine Date: 2016-03-10 Impact factor: 8.143

5. Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability.

Authors: Arianna Colosio; Camilla Frattini; Grazia Pellicanò; Sara Villa-Hernández; Rodrigo Bermejo
Journal: Nucleic Acids Res Date: 2016-09-26 Impact factor: 16.971

Dna2 offers support for stalled forks.

1. Replication forks reverse at high frequency upon replication stress in Physarum polycephalum.

2. Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit.

3. Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.

4. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy.

5. Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability.

6. Disease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication.

7. Structural insights into DNA degradation by human mitochondrial nuclease MGME1.

Review 8. Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases.