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Literature DB >> 22682218

Polarizing macrophages through reprogramming of glucose metabolism.

Abstract

Reprogramming of intracellular metabolism is common in activated immune cells. In this issue of Cell Metabolism, Haschemi et al. (2012) show that the sedoheptulose kinase CARKL is required for metabolic reprogramming in activated macrophages and provide evidence that changes in glucose metabolism and the pentose phosphate pathway (PPP) influences macrophage polarization.

Entities: Chemical Gene

Year: 2012 PMID： 22682218 DOI： 10.1016/j.cmet.2012.05.008

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

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Cited

28 in total

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Polarizing macrophages through reprogramming of glucose metabolism.

1. Liraglutide targets the gut microbiota and the intestinal immune system to regulate insulin secretion.

2. Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response.

Review 3. Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus.

4. Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease.

5. Heme catabolism by tumor-associated macrophages controls metastasis formation.

Review 6. Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma.

7. Macrophages Promote Oxidative Metabolism To Drive Nitric Oxide Generation in Response to Trypanosoma cruzi.

8. An association between mitochondria and microglia effector function. What do we think we know?

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10. Metabolomic Reprogramming of C57BL/6-Macrophages during Early Infection with L. amazonensis.