| Literature DB >> 22682057 |
Theresa A Lansdell1, Sandra O'Reilly, Tracey Woolliscroft, Lauren M Azevedo, Daljinder K Kahlon, Stacy Hovde, J Justin McCormick, R William Henry, Joseph A Cornicelli, Jetze J Tepe.
Abstract
The pathogenesis of rheumatoid arthritis is mainly driven by NF-κB-mediated production of cytokines, such as TNF-α. We report herein that the orally available imidazoline-based NF-κB inhibitor, TCH-013, was found to significantly reduce TNF-α signaling and attenuate collagen antibody induced arthritis in BALB/c mice.Entities:
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Year: 2012 PMID： 22682057 DOI： 10.1016/j.bmcl.2012.05.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823