Literature DB >> 22681883

Stemming danger with Golgified BAX.

Loren D Walensky1.   

Abstract

In this issue of Molecular Cell, Dumitru et al. (2012) report that hES cells localize a conformationally activated form of proapoptotic BAX to the trans Golgi network, a previously unanticipated launch pad for mitochondrial assault in response to DNA damage.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22681883      PMCID： PMC3839817          DOI： 10.1016/j.molcel.2012.05.034

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  9 in total

1.  Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

Authors:  A R Khaled; K Kim; R Hofmeister; K Muegge; S K Durum
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

2.  Structure of Bax: coregulation of dimer formation and intracellular localization.

Authors:  M Suzuki; R J Youle; N Tjandra
Journal:  Cell       Date:  2000-11-10       Impact factor: 41.582

3.  BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

Authors:  Evripidis Gavathiotis; Denis E Reyna; Marguerite L Davis; Gregory H Bird; Loren D Walensky
Journal:  Mol Cell       Date:  2010-11-12       Impact factor: 17.970

4.  Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism.

Authors:  Nai Yang Fu; Sunil K Sukumaran; Sze Yen Kerk; Victor C Yu
Journal:  Mol Cell       Date:  2009-01-16       Impact factor: 17.970

5.  Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.

Authors:  M Sattler; H Liang; D Nettesheim; R P Meadows; J E Harlan; M Eberstadt; H S Yoon; S B Shuker; B S Chang; A J Minn; C B Thompson; S W Fesik
Journal:  Science       Date:  1997-02-14       Impact factor: 47.728

6.  The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

Authors:  Lisa J Pagliari; Tomomi Kuwana; Christine Bonzon; Donald D Newmeyer; Shine Tu; Helen M Beere; Douglas R Green
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-05       Impact factor: 11.205

7.  Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.

Authors:  Frank Edlich; Soojay Banerjee; Motoshi Suzuki; Megan M Cleland; Damien Arnoult; Chunxin Wang; Albert Neutzner; Nico Tjandra; Richard J Youle
Journal:  Cell       Date:  2011-04-01       Impact factor: 41.582

8.  Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis.

Authors:  Raluca Dumitru; Vivian Gama; B Matthew Fagan; Jacquelyn J Bower; Vijay Swahari; Larysa H Pevny; Mohanish Deshmukh
Journal:  Mol Cell       Date:  2012-05-03       Impact factor: 17.970

9.  Movement of Bax from the cytosol to mitochondria during apoptosis.

Authors:  K G Wolter; Y T Hsu; C L Smith; A Nechushtan; X G Xi; R J Youle
Journal:  J Cell Biol       Date:  1997-12-01       Impact factor: 10.539
  9 in total
  1 in total

1.  MCL-1 Inhibition by Selective BH3 Mimetics Disrupts Mitochondrial Dynamics Causing Loss of Viability and Functionality of Human Cardiomyocytes.

Authors:  Megan L Rasmussen; Nilay Taneja; Abigail C Neininger; Lili Wang; Gabriella L Robertson; Stellan N Riffle; Linzheng Shi; Bjorn C Knollmann; Dylan T Burnette; Vivian Gama
Journal:  iScience       Date:  2020-03-30
  1 in total

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