OBJECTIVE: To investigate the development of lung function in HIV-infected patients. METHODS: In a prospective cohort study, 88 HIV-infected patients had a lung function test performed and 63 patients (72%) had their LFT repeated with a median follow-up period of 4.4 years. Forty-eight per cent were smokers, and at the re-examination, 97% were on combination antiretroviral therapy. RESULTS: Carbon monoxide diffusion capacity was reduced and decreased over time in both smokers and non-smokers. Alveolar volume decreased and forced vital capacity increased similarly in both smokers and non-smokers. No changes were observed in forced expiratory volume or peak flow, but smokers had reduced values compared with those of the non-smokers at both examinations. FEV1/FVC was reduced especially in smokers and declined in both smokers and non-smokers. CONCLUSIONS: Carbon monoxide diffusion capacity is reduced in HIV-infected patients and seems to decline over time. Additionally, signs of obstructive lung disease are present in HIV-infected patients and seem to increase over time, although only modestly.
OBJECTIVE: To investigate the development of lung function in HIV-infectedpatients. METHODS: In a prospective cohort study, 88 HIV-infectedpatients had a lung function test performed and 63 patients (72%) had their LFT repeated with a median follow-up period of 4.4 years. Forty-eight per cent were smokers, and at the re-examination, 97% were on combination antiretroviral therapy. RESULTS:Carbon monoxide diffusion capacity was reduced and decreased over time in both smokers and non-smokers. Alveolar volume decreased and forced vital capacity increased similarly in both smokers and non-smokers. No changes were observed in forced expiratory volume or peak flow, but smokers had reduced values compared with those of the non-smokers at both examinations. FEV1/FVC was reduced especially in smokers and declined in both smokers and non-smokers. CONCLUSIONS:Carbon monoxide diffusion capacity is reduced in HIV-infectedpatients and seems to decline over time. Additionally, signs of obstructive lung disease are present in HIV-infectedpatients and seem to increase over time, although only modestly.
Authors: Matthew Triplette; Amy Justice; Engi F Attia; Janet Tate; Sheldon T Brown; Matthew Bidwell Goetz; Joon W Kim; Maria C Rodriguez-Barradas; Guy W Soo Hoo; Cherry Wongtrakool; Kathleen Akgün; Kristina Crothers Journal: AIDS Date: 2018-02-20 Impact factor: 4.177
Authors: Jessica L Montoya; Catherine M Jankowski; Kelly K O'Brien; Allison R Webel; Krisann K Oursler; Brook L Henry; David J Moore; Kristine M Erlandson Journal: AIDS Date: 2019-05-01 Impact factor: 4.177
Authors: Kristine M Erlandson; Samantha MaWhinney; Melissa Wilson; Lilyana Gross; Sean A McCandless; Thomas B Campbell; Wendy M Kohrt; Robert Schwartz; Todd T Brown; Catherine M Jankowski Journal: AIDS Date: 2018-10-23 Impact factor: 4.177
Authors: William T Shearer; Denise L Jacobson; Wendy Yu; George K Siberry; Murli Purswani; Suzanne Siminski; Laurie Butler; Erin Leister; Gwendolyn Scott; Russell B Van Dyke; Ram Yogev; Mary E Paul; Ana Puga; Andrew A Colin; Meyer Kattan Journal: J Allergy Clin Immunol Date: 2017-03-06 Impact factor: 10.793