| Literature DB >> 22681507 |
Toshihiro Hamada1, Kensaku Yamada, Einosuke Mizuta, Arisa Watanabe, Tomohiro Osaki, Katsunori Ishida, Akira Hasegawa, Shinji Sakata, Mutsuo Mishima, Kazuhide Ogino, Yoshihito Nosaka, Satoshi Miyazaki, Akira Ohtahara, Haruaki Ninomiya, Masahiko Kato, Akio Yoshida, Shin-ichi Taniguchi, Kazuhiro Yamamoto, Ichiro Hisatome.
Abstract
The effects of cilnidipine on the serum uric acid level and urinary NO excretion in hypertensive patients were investigated. Blood and urine samples of 16 hypertensive outpatients were collected before and 2 months after cilnidipine therapy (10 mg). The serum uric acid level decreased significantly after cilnidipine treatment, while the uric acid-creatinine clearance ratio was unaffected. The cilnidipine medication produced a significant increase in urinary NO excretion, although amlodipine did not change it significantly. Therefore, cilnidipine has a profound antihypertensive effect and may reduce the serum uric acid level and increase NO production in the kidney.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22681507 DOI： 10.3109/10641963.2012.666600
Source DB: PubMed Journal: Clin Exp Hypertens ISSN： 1064-1963 Impact factor: 1.749