L L Carpenter1, C E Gawuga, A R Tyrka, L H Price. 1. Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, RI, USA.
Abstract
OBJECTIVE: To determine whether C-reactive protein (CRP) can serve as a marker for alterations in immune function prior to the manifestation of significant psychiatric and medical disorders. METHOD: Ninety-two healthy adults were recruited from the community and determined to be free of psychiatric or medical disorders. The concentration of plasma CRP from a single resting sample was examined in relation to current mental and physical health as well as to self-reported history of early life adversity. RESULTS: C-reactive protein showed a significant positive correlation with body mass index (BMI; r = 0.477, P < 0.001). Non-specific pain, fatigue, and lower overall quality of physical health were all associated with higher CRP concentrations (all P < 0.05 or P < 0.01), after controlling for effect of BMI and other relevant covariates. Subthreshold depression symptoms and other indices of mental/emotional wellbeing were not associated with CRP, nor was CRP significantly linked to any measures of early life adversity. CONCLUSION: Lower-quality physical health and wellbeing, but not the presence of mood/anxiety symptoms or early life stress (ELS), were significantly related to plasma CRP. Elevated CRP does not appear to be a fundamental consequence of ELS among healthy adults.
OBJECTIVE: To determine whether C-reactive protein (CRP) can serve as a marker for alterations in immune function prior to the manifestation of significant psychiatric and medical disorders. METHOD: Ninety-two healthy adults were recruited from the community and determined to be free of psychiatric or medical disorders. The concentration of plasma CRP from a single resting sample was examined in relation to current mental and physical health as well as to self-reported history of early life adversity. RESULTS:C-reactive protein showed a significant positive correlation with body mass index (BMI; r = 0.477, P < 0.001). Non-specific pain, fatigue, and lower overall quality of physical health were all associated with higher CRP concentrations (all P < 0.05 or P < 0.01), after controlling for effect of BMI and other relevant covariates. Subthreshold depression symptoms and other indices of mental/emotional wellbeing were not associated with CRP, nor was CRP significantly linked to any measures of early life adversity. CONCLUSION: Lower-quality physical health and wellbeing, but not the presence of mood/anxiety symptoms or early life stress (ELS), were significantly related to plasma CRP. Elevated CRP does not appear to be a fundamental consequence of ELS among healthy adults.
Authors: Allison A Appleton; Stephen L Buka; Marie C McCormick; Karestan C Koenen; Eric B Loucks; Stephen E Gilman; Laura D Kubzansky Journal: Psychosom Med Date: 2011-05-02 Impact factor: 4.312
Authors: Pekka Johannes Puustinen; Hannu Koponen; Hannu Kautiainen; Pekka Mäntyselkä; Mauno Vanhala Journal: Eur Arch Psychiatry Clin Neurosci Date: 2010-08-14 Impact factor: 5.270
Authors: Carissa A Low; Amy Lynn Cunningham; Amy H Kao; Shanthi Krishnaswami; Lewis H Kuller; Mary Chester M Wasko Journal: Biol Psychol Date: 2009-02-23 Impact factor: 3.251
Authors: Andrew J Fuligni; Eva H Telzer; Julienne Bower; Steve W Cole; Lisa Kiang; Michael R Irwin Journal: Psychosom Med Date: 2009-02-05 Impact factor: 4.312
Authors: Sarah R Horn; Madison M Long; Benjamin W Nelson; Nicholas B Allen; Philip A Fisher; Michelle L Byrne Journal: Brain Behav Immun Date: 2018-06-19 Impact factor: 7.217
Authors: Marin M Kautz; Christopher L Coe; Brae Anne McArthur; Naoise Mac Giollabhui; Lauren M Ellman; Lyn Y Abramson; Lauren B Alloy Journal: Brain Behav Immun Date: 2019-02-26 Impact factor: 7.217
Authors: M Tursich; R W J Neufeld; P A Frewen; S Harricharan; J L Kibler; S G Rhind; R A Lanius Journal: Transl Psychiatry Date: 2014-07-22 Impact factor: 6.222