Literature DB >> 22681478

2-Azabicyclo[2.2.1]hept-5-en-3-one: chemical profile of a versatile synthetic building block and its impact on the development of therapeutics.

Rohit Singh1, Robert Vince.   

Abstract

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Year:  2012        PMID： 22681478     DOI： 10.1021/cr2004822

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


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  15 in total

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6.  Engineering the Enantioselectivity and Thermostability of a (+)-γ-Lactamase from Microbacterium hydrocarbonoxydans for Kinetic Resolution of Vince Lactam (2-Azabicyclo[2.2.1]hept-5-en-3-one).

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Journal:  Appl Environ Microbiol       Date:  2017-12-15       Impact factor: 4.792

7.  Structural insights into the γ-lactamase activity and substrate enantioselectivity of an isochorismatase-like hydrolase from Microbacterium hydrocarbonoxydans.

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8.  Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase.

Authors:  Sida Shen; Arseniy Butrin; Peter F Doubleday; Rafael D Melani; Brett A Beaupre; Mauricio T Tavares; Glaucio M Ferreira; Neil L Kelleher; Graham R Moran; Dali Liu; Richard B Silverman
Journal:  J Am Chem Soc       Date:  2021-06-07       Impact factor: 16.383

9.  CBD binding domain fused γ-lactamase from Sulfolobus solfataricus is an efficient catalyst for (-) γ-lactam production.

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