OBJECTIVE: To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its association with different types of common bronchogenic carcinomas using routine white light bronchoscopy. METHODS: Using a case-control design, 186 formalin-fixed paraffin-embedded blocks of bronchial tissue (136 cases, 50 controls) obtained from patients who underwent routine nonfluorescence bronchoscopy between 2004 and 2005 were studied. RESULTS: ASD occurred at a higher frequency in patients with neoplastic lesions compared with those without neoplastic lesions (28 of 136 versus one of 50). ASD was also more prevalent in patients with squamous cell carcinoma compared with other neoplasms. Seventy six per cent of the ASD patients (22 of 29) smoked cigarettes. The morphology of ASD on hematoxylin and eosin- and CD31-stained sections was characterized by prominent microvasculature and capillary projections closely juxtaposed to variable degrees of dysplasia in all of the bronchogenic carcinoma specimens, and to metaplasia in one case in the control group. CONCLUSION: ASD is a unique morphological entity that should be considered by pathologists even on bronchoscopic biopsies from patients who undergo white light bronchoscopy. The presence of ASD may represent a risk biomarker of bronchogenic carcinoma in screening programs and in chemoprevention of lung cancer.
OBJECTIVE: To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its association with different types of common bronchogenic carcinomas using routine white light bronchoscopy. METHODS: Using a case-control design, 186 formalin-fixed paraffin-embedded blocks of bronchial tissue (136 cases, 50 controls) obtained from patients who underwent routine nonfluorescence bronchoscopy between 2004 and 2005 were studied. RESULTS:ASD occurred at a higher frequency in patients with neoplastic lesions compared with those without neoplastic lesions (28 of 136 versus one of 50). ASD was also more prevalent in patients with squamous cell carcinoma compared with other neoplasms. Seventy six per cent of the ASDpatients (22 of 29) smoked cigarettes. The morphology of ASD on hematoxylin and eosin- and CD31-stained sections was characterized by prominent microvasculature and capillary projections closely juxtaposed to variable degrees of dysplasia in all of the bronchogenic carcinoma specimens, and to metaplasia in one case in the control group. CONCLUSION:ASD is a unique morphological entity that should be considered by pathologists even on bronchoscopic biopsies from patients who undergo white light bronchoscopy. The presence of ASD may represent a risk biomarker of bronchogenic carcinoma in screening programs and in chemoprevention of lung cancer.
Authors: R L Keith; Y E Miller; R M Gemmill; H A Drabkin; E C Dempsey; T C Kennedy; S Prindiville; W A Franklin Journal: Clin Cancer Res Date: 2000-05 Impact factor: 12.531
Authors: G Fontanini; A Calcinai; L Boldrini; M Lucchi; A Mussi; C A Angeletti; C Cagno; M A Tognetti; F Basolo Journal: Oncol Rep Date: 1999 Jul-Aug Impact factor: 3.906
Authors: G Fontanini; S Vignati; D Bigini; M Lucchi; A Mussi; F Basolo; C A Angeletti; G Bevilacqua Journal: Int J Cancer Date: 1996-09-04 Impact factor: 7.396
Authors: Daniel T Merrick; Dexiang Gao; York E Miller; Robert L Keith; Anna E Baron; William Feser; Timothy C Kennedy; Patrick J Blatchford; Sarah Braudrick; Fred R Hirsch; Lynn Heasley; Paul A Bunn; Wilbur A Franklin Journal: Cancer Prev Res (Phila) Date: 2015-11-05