BACKGROUND: Much variation is found in the development of hand function in children with unilateral cerebral palsy (CP). OBJECTIVE: . To explore how anatomic brain abnormalities can be used to predict the development of hand function. METHODS: A total of 32 children with unilateral CP (16 boys and 16 girls) were evaluated at least once a year by the Assisting Hand Assessment (AHA). The data collection covered an age range from 18 months to 8 years (mean time in study, 4 years and 6 months). Computerized tomography or magnetic resonance imaging of the brain were assessed for patterns of brain damage, including the location of gray and extent of white-matter damage. The children were divided into groups according to lesion characteristics, and a series of univariate models were analyzed with a nonlinear mixed-effects model. The rate and maximum limit of development were calculated. RESULTS: The highest predictive power of better development of hand function was the absence of a concurrent lesion to the basal ganglia and thalamus, independent of the basic type of brain lesion. This model predicted both the rate of increasing ability and hand function at age 8 years. Hand function was also predicted by the basic pattern of damage and by the extent of white-matter damage. The presence of unilateral or bilateral damage had no predictive value. CONCLUSIONS: Neuroradiological findings can be used to make a crude prediction of the future development of the use of the affected hand in young children with unilateral CP.
BACKGROUND: Much variation is found in the development of hand function in children with unilateral cerebral palsy (CP). OBJECTIVE: . To explore how anatomic brain abnormalities can be used to predict the development of hand function. METHODS: A total of 32 children with unilateral CP (16 boys and 16 girls) were evaluated at least once a year by the Assisting Hand Assessment (AHA). The data collection covered an age range from 18 months to 8 years (mean time in study, 4 years and 6 months). Computerized tomography or magnetic resonance imaging of the brain were assessed for patterns of brain damage, including the location of gray and extent of white-matter damage. The children were divided into groups according to lesion characteristics, and a series of univariate models were analyzed with a nonlinear mixed-effects model. The rate and maximum limit of development were calculated. RESULTS: The highest predictive power of better development of hand function was the absence of a concurrent lesion to the basal ganglia and thalamus, independent of the basic type of brain lesion. This model predicted both the rate of increasing ability and hand function at age 8 years. Hand function was also predicted by the basic pattern of damage and by the extent of white-matter damage. The presence of unilateral or bilateral damage had no predictive value. CONCLUSIONS: Neuroradiological findings can be used to make a crude prediction of the future development of the use of the affected hand in young children with unilateral CP.
Authors: S I Shiran; M Weinstein; C Sirota-Cohen; V Myers; D Ben Bashat; A Fattal-Valevski; D Green; M Schertz Journal: AJNR Am J Neuroradiol Date: 2014-05-22 Impact factor: 3.825
Authors: Claudio L Ferre; Jason B Carmel; Véronique H Flamand; Andrew M Gordon; Kathleen M Friel Journal: Neurorehabil Neural Repair Date: 2020-01-26 Impact factor: 3.919
Authors: Nathalie L Maitre; Gena Henderson; Shirley Gogliotti; Jennifer Pearson; Ashley Simmons; Lu Wang; James C Slaughter; Alexandra P Key Journal: J Clin Exp Neuropsychol Date: 2014-06-23 Impact factor: 2.475
Authors: Brian J Hoare; Margaret A Wallen; Megan N Thorley; Michelle L Jackman; Leeanne M Carey; Christine Imms Journal: Cochrane Database Syst Rev Date: 2019-04-01
Authors: Roslyn N Boyd; Rachel Jordan; Laura Pareezer; Anne Moodie; Christine Finn; Belinda Luther; Evyn Arnfield; Aaron Pym; Alex Craven; Paula Beall; Kelly Weir; Megan Kentish; Meredith Wynter; Robert Ware; Michael Fahey; Barry Rawicki; Lynne McKinlay; Andrea Guzzetta Journal: BMC Neurol Date: 2013-06-11 Impact factor: 2.474