Literature DB >> 22677312

Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer.

Jason N Mock1, John P Taliaferro, Xiao Lu, Sravan Kumar Patel, Brian S Cummings, Timothy E Long.   

Abstract

Haloenol pyran-2-ones and morpholin-2-ones were synthesized and evaluated as inhibitors of cell growth in two different prostate human cancer cell lines (PC-3 and LNCaP). Analogs derived from L- and D-phenylglycine were found to be the most effective antagonists of LNCaP and PC-3 cell growth. Additional studies reveal that the inhibitors induced G2/M arrest and the (S)-enantiomer of the phenylglycine-based derivatives was a more potent inhibitor of cytosolic iPLA(2)β. Published by Elsevier Ltd.

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Year:  2012        PMID： 22677312      PMCID： PMC3376906          DOI： 10.1016/j.bmcl.2012.05.038

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  52 in total

1.  Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease.

Authors:  J J Hoozemans; R Veerhuis; I Janssen; A J Rozemuller; P Eikelenboom
Journal:  Exp Gerontol       Date:  2001-03       Impact factor: 4.032

2.  Expression of group IIa secretory phospholipase A2 increases with prostate tumor grade.

Authors:  J R Graff; B W Konicek; J A Deddens; M Chedid; B M Hurst; B Colligan; B L Neubauer; H W Carter; J H Carter
Journal:  Clin Cancer Res       Date:  2001-12       Impact factor: 12.531

3.  Phosphorylation of cytosolic group IV phospholipase A(2) is necessary but not sufficient for Arachidonic acid release in P388D(1) macrophages.

Authors:  M A Balboa; J Balsinde; E A Dennis
Journal:  Biochem Biophys Res Commun       Date:  2000-01-07       Impact factor: 3.575

4.  Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels.

Authors:  J Balsinde; M A Balboa; W H Li; J Llopis; E A Dennis
Journal:  J Immunol       Date:  2000-05-15       Impact factor: 5.422

5.  Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes.

Authors:  Jianfeng Xu; Yu-I Weng; Agnes Simonyi; Brent W Krugh; Zhongji Liao; Gary A Weisman; Grace Y Sun; Agnes Simoni
Journal:  J Neurochem       Date:  2002-10       Impact factor: 5.372

Review 6.  Phospholipase A(2)s in cell injury and death.

Authors:  B S Cummings; J McHowat; R G Schnellmann
Journal:  J Pharmacol Exp Ther       Date:  2000-09       Impact factor: 4.030

7.  Expression of group IIA secretory phospholipase A2 is elevated in prostatic intraepithelial neoplasia and adenocarcinoma.

Authors:  Jiazhong Jiang; Blake Lee Neubauer; Jeremy R Graff; Marcio Chedid; James E Thomas; Neal W Roehm; Shaobo Zhang; George J Eckert; Michael O Koch; John N Eble; Liang Cheng
Journal:  Am J Pathol       Date:  2002-02       Impact factor: 4.307

8.  Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance.

Authors:  Katsunori Tsuboi; Daniel A Bachovchin; Anna E Speers; Timothy P Spicer; Virneliz Fernandez-Vega; Peter Hodder; Hugh Rosen; Benjamin F Cravatt
Journal:  J Am Chem Soc       Date:  2011-09-27       Impact factor: 15.419

9.  Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s.

Authors:  Christopher M Jenkins; Xianlin Han; David J Mancuso; Richard W Gross
Journal:  J Biol Chem       Date:  2002-06-27       Impact factor: 5.157

10.  Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways.

Authors:  Brian S Cummings; Rick G Schnellmann
Journal:  J Pharmacol Exp Ther       Date:  2002-07       Impact factor: 4.030
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  1 in total

1.  Towards lipidomics of low-abundant species for exploring tumor heterogeneity guided by high-resolution mass spectrometry imaging.

Authors:  Jonathan Cimino; David Calligaris; Johann Far; Delphine Debois; Silvia Blacher; Nor Eddine Sounni; Agnès Noel; Edwin De Pauw
Journal:  Int J Mol Sci       Date:  2013-12-17       Impact factor: 5.923
  1 in total

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