M Schnoor1, A Waldmann, A Eberle, B Holleczek, A Katalinic. 1. Institute of Clinical Epidemiology, University Hospital Schleswig-Holstein, Campus Luebeck, RatzeburgerAllee 160, 23562 Luebeck, Germany. maike.schnoor@uksh.de
Abstract
BACKGROUND: In 2002, colonoscopy was introduced as a tool for colorectal cancer screening in Germany. The long-term objective was to reduce the incidence in colorectal cancer (CRC) by detection and removal of advanced adenomas. Currently, the effect of colonoscopy screening on the population-based incidence of CRC in Germany is unknown. METHODS: We provide data on stage-specific (age-standardized) incidence rates in three federal states in Germany, 6 years after the implementation of colonoscopy. RESULTS: Between 2002 and 2008 a statistically significant decrease in CRC incidence could be observed (annually 3.0%, 95% confidence interval [CI]: -3.8; -2.2). The decline could be observed in all advanced tumor categories (T2, T3, and T4), whereas the incidence of in situ carcinomas (Tis) increased annually by 51.6% (95% CI: 28.0; 79.4) until 2004, and remained stable until 2008. CONCLUSION: The observed changes cannot be attributed definitively to the screening activities, but the presented data support a possible causal association.
BACKGROUND: In 2002, colonoscopy was introduced as a tool for colorectal cancer screening in Germany. The long-term objective was to reduce the incidence in colorectal cancer (CRC) by detection and removal of advanced adenomas. Currently, the effect of colonoscopy screening on the population-based incidence of CRC in Germany is unknown. METHODS: We provide data on stage-specific (age-standardized) incidence rates in three federal states in Germany, 6 years after the implementation of colonoscopy. RESULTS: Between 2002 and 2008 a statistically significant decrease in CRC incidence could be observed (annually 3.0%, 95% confidence interval [CI]: -3.8; -2.2). The decline could be observed in all advanced tumor categories (T2, T3, and T4), whereas the incidence of in situ carcinomas (Tis) increased annually by 51.6% (95% CI: 28.0; 79.4) until 2004, and remained stable until 2008. CONCLUSION: The observed changes cannot be attributed definitively to the screening activities, but the presented data support a possible causal association.
Authors: Joachim Hübner; Philip Lewin; Ron Pritzkuleit; Nora Eisemann; Werner Maier; Alexander Katalinic Journal: Int J Colorectal Dis Date: 2019-01-10 Impact factor: 2.571
Authors: Nora Eisemann; Annika Waldmann; Alan C Geller; Martin A Weinstock; Beate Volkmer; Ruediger Greinert; Eckhard W Breitbart; Alexander Katalinic Journal: J Invest Dermatol Date: 2013-07-22 Impact factor: 8.551
Authors: Hermann Brenner; Petra Schrotz-King; Bernd Holleczek; Alexander Katalinic; Michael Hoffmeister Journal: Dtsch Arztebl Int Date: 2016-02-19 Impact factor: 5.594